Phenotypes associated with this allele

• Allele Symbol: Tlr4^lps-Btlr
• Allele Name: defective lipopolysaccharide response Bruce Beutler
• Allele ID: MGI:3767575
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr4^lps-Btlr/Tlr4^lps-Btlr	C57BL/6J-Tlr4^lps-Btlr	MGI:3767576

Genotype
MGI:3767576

hm1

• Allelic Composition: Tlr4^lps-Btlr/Tlr4^lps-Btlr
• Genetic Background: C57BL/6J-Tlr4^lps-Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:128416 )

• peritoneal macrophages from homozygous mutant mice produce no tumor necrosis factor (TNF-) alpha in response to stimulation with lipopolysaccharide (LPS)

• peritoneal macrophages from homozygous mutant mice fail to produce type I interferon (IFN) in response to LPS

• TNF-alpha production by homozygous mutant macrophages is normal following stimulation with MALP-2 (macrophage-activating lipopeptide-2, a TLR2/6 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand), CpG oligodeoxynucleotides (a TLR9 ligand), R-848/resiquimod, (a single-stranded RNA mimetic and TLR7 ligand), and peptidoglycan

hematopoietic system

abnormal macrophage physiology ( J:128416 )

• peritoneal macrophages from homozygous mutant mice produce no tumor necrosis factor (TNF-) alpha in response to stimulation with lipopolysaccharide (LPS)

• peritoneal macrophages from homozygous mutant mice fail to produce type I interferon (IFN) in response to LPS

• TNF-alpha production by homozygous mutant macrophages is normal following stimulation with MALP-2 (macrophage-activating lipopeptide-2, a TLR2/6 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand), CpG oligodeoxynucleotides (a TLR9 ligand), R-848/resiquimod, (a single-stranded RNA mimetic and TLR7 ligand), and peptidoglycan