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Allele Symbol Allele Name Allele ID |
Fbxw7tm1Kei targeted mutation 1, Keiichi Nakayama MGI:3767577 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop double positive lymphomas at increased frequency and decreased latency compared to Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Lck-cre)1Cwi mice
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• at 8 weeks of age 2 mice develop thymic lymphoma
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• at 8 weeks of age 2 mice develop thymic lymphoma
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| N |
• unlike in Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Lck-cre)1Cwi mice, T cells do not arrest in S phase or undergo increased apoptosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in Fbxw7tm1Kei/Fbxw7tm1Kei Tg(CD4-cre)1Cwi mice, the number of double positive thymocytes is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice that develop lymphomas die between 14 and 60 weeks
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• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased
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• the number and percent of double positive thymocytes is increased compared to in wild-type mice due to increased proliferation of double positive thymocytes
• however, the number and proliferation of double negative, CD4+ single positive and CD8+ single positive thymocytes are normal
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• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes
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• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes
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• T cells fail to proliferate in response to anti-CD3 or the combination of phorbol 12,13-dibutyrate and ionomycin
• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased
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• 12 of 23 mice develop aggressive lymphomas with massive thymic enlargement due to clonal expansion of double positive thymocytes
• tumors contain uniform populations of immature lymphoid cells with some areas of necrosis
• early and late onset tumors exhibit identical phenotype
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• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased
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• the number and percent of double positive thymocytes is increased compared to in wild-type mice due to increased proliferation of double positive thymocytes
• however, the number and proliferation of double negative, CD4+ single positive and CD8+ single positive thymocytes are normal
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• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes
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• the number of single positive T cells is decreased in peripheral organs such as the spleen and lymph nodes
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• T cells fail to proliferate in response to anti-CD3 or the combination of phorbol 12,13-dibutyrate and ionomycin
• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased
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• after stimulation with antigen, T cell progression into S phase is inhibited and apoptosis is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the number and percent of double positive thymocytes is increased compared to in wild-type mice but not as much as in Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Lck-cre)1Cwi mice
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• the number and percent of double positive thymocytes is increased compared to in wild-type mice but not as much as in Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Lck-cre)1Cwi mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the number and percent of double positive thymocytes is increased compared to in wild-type mice
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• the number and percent of double positive thymocytes is increased compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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