All Phenotypes Bcl11b<tm1Avram> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tg(Cd4-cre)1Cwi/?	involves: 129 * C57BL/6 * DBA/2	MGI:3767629
cn2	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tcra^tm1Mom/Tcra^tm1Mom Tg(Cd4-cre)1Cwi/?	involves: 129 * C57BL/6 * DBA/2	MGI:3767630
cn3	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tg(Cd4-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/?	involves: 129 * C57BL/6 * DBA/2	MGI:3767631

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal thymocyte activation ( J:128515 )

• double positive T cells have attenuated TCR signaling as determined by reduced Ca flux and phosphorylation of downstream signaling proteins after TCR stimulation

increased spleen weight ( J:128515 )

• 2.5 fold increase in spleen weight to bodyweight ratio

spleen hyperplasia ( J:128515 )

• 1.9 fold increase in spleen cellularity

abnormal leukocyte morphology ( J:128515 )

abnormal positive T cell selection ( J:128515 )

• 20 fold reduction in the percentage of double positive T cells that express surface markers associated with passage through the double positive stage

• slight increase in the number of apoptotic double positive T cells occurs after 16 hours in culture

decreased double-negative T cell number ( J:128515 )

• 45% reduction in the number of DN T cells in the thymus

decreased double-positive T cell number ( J:128515 )

• 43% reduction in the number of DP T cells in the thymus

increased dendritic cell number ( J:128515 )

• about a 5 fold increase in the number of dendritic cells found in the spleen

increased B cell number ( J:128515 )

• 2-5 fold increase in the number of B cells in the spleen and lymph nodes

increased NK cell number ( J:128515 )

• about a 3.5 fold increase in the number of NK cells found in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:128515 )

• 2 to 5 fold reduction in the number of CD4 T cells in the spleen and lymph nodes

• 10 fold reduction in single positive CD4 T cells in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:128515 )

• 2 to 3 fold reduction in the number of CD8 T cells in the spleen and lymph nodes

• 10 fold reduction in single positive CD8 T cells in the thymus

increased gamma-delta T cell number ( J:128515 )

• about a 3 fold increase in the number of gamma-delta T cells found in the spleen

immune system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal thymocyte activation ( J:128515 )

• double positive T cells have attenuated TCR signaling as determined by reduced Ca flux and phosphorylation of downstream signaling proteins after TCR stimulation

increased spleen weight ( J:128515 )

• 2.5 fold increase in spleen weight to bodyweight ratio

spleen hyperplasia ( J:128515 )

• 1.9 fold increase in spleen cellularity

abnormal leukocyte morphology ( J:128515 )

abnormal positive T cell selection ( J:128515 )

• 20 fold reduction in the percentage of double positive T cells that express surface markers associated with passage through the double positive stage

• slight increase in the number of apoptotic double positive T cells occurs after 16 hours in culture

decreased double-negative T cell number ( J:128515 )

• 45% reduction in the number of DN T cells in the thymus

decreased double-positive T cell number ( J:128515 )

• 43% reduction in the number of DP T cells in the thymus

increased dendritic cell number ( J:128515 )

• about a 5 fold increase in the number of dendritic cells found in the spleen

increased B cell number ( J:128515 )

• 2-5 fold increase in the number of B cells in the spleen and lymph nodes

increased NK cell number ( J:128515 )

• about a 3.5 fold increase in the number of NK cells found in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:128515 )

• 2 to 5 fold reduction in the number of CD4 T cells in the spleen and lymph nodes

• 10 fold reduction in single positive CD4 T cells in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:128515 )

• 2 to 3 fold reduction in the number of CD8 T cells in the spleen and lymph nodes

• 10 fold reduction in single positive CD8 T cells in the thymus

increased gamma-delta T cell number ( J:128515 )

• about a 3 fold increase in the number of gamma-delta T cells found in the spleen

enlarged mesenteric lymph nodes ( J:128515 )

• there are twice the number of cells within the mesenteric lymph nodes as compared to control mice

endocrine/exocrine glands

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal thymocyte activation ( J:128515 )

• double positive T cells have attenuated TCR signaling as determined by reduced Ca flux and phosphorylation of downstream signaling proteins after TCR stimulation

growth/size/body

increased spleen weight ( J:128515 )

• 2.5 fold increase in spleen weight to bodyweight ratio

spleen hyperplasia ( J:128515 )

• 1.9 fold increase in spleen cellularity

Allelic Composition	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tcra^tm1Mom/Tcra^tm1Mom Tg(Cd4-cre)1Cwi/?
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11b^tm1Avram mutation (0 available); any Bcl11b mutation (46 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal positive T cell selection ( J:128515 )

• slight increase in the number of apoptotic double positive T cells after 16 hours of culturing, indicating apoptosis is occurring independent of TCR signaling

decreased double-positive T cell number ( J:128515 )

• 2.4 fold reduction in the number of DP T cells in thymus

immune system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal positive T cell selection ( J:128515 )

• slight increase in the number of apoptotic double positive T cells after 16 hours of culturing, indicating apoptosis is occurring independent of TCR signaling

decreased double-positive T cell number ( J:128515 )

• 2.4 fold reduction in the number of DP T cells in thymus

endocrine/exocrine glands

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

Allelic Composition	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tg(Cd4-cre)1Cwi/? Tg(LCKprBCL2)36Sjk/?
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11b^tm1Avram mutation (0 available); any Bcl11b mutation (46 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:128515 )

• 94% reduction in cellularity

abnormal positive T cell selection ( J:128515 )

• slightly less apoptotic double positive T cells after 16 hours of culturing compared to transgenic mice that do not express Cre recombinase

decreased double-positive T cell number ( J:128515 )

• 93% reduction in number of double positive T cells

decreased CD4-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

decreased CD8-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

immune system

thymus hypoplasia ( J:128515 )

• 94% reduction in cellularity

abnormal positive T cell selection ( J:128515 )

• slightly less apoptotic double positive T cells after 16 hours of culturing compared to transgenic mice that do not express Cre recombinase

decreased double-positive T cell number ( J:128515 )

• 93% reduction in number of double positive T cells

decreased CD4-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

decreased CD8-positive, alpha-beta T cell number ( J:128515 )

• 91% reduction in number single positive CD4 T cells

endocrine/exocrine glands

thymus hypoplasia ( J:128515 )

• 94% reduction in cellularity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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