Phenotypes associated with this allele

• Allele Symbol: Sort1^tm1Tew
• Allele Name: targeted mutation 1, Thomas E Willnow
• Allele ID: MGI:3767625
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sort1^tm1Tew/Sort1^tm1Tew	B6.129-Sort1^tm1Tew	MGI:3767628
cx2	Ngf^tm1.1Blhe/Ngf^+ Sort1^tm1Tew/Sort1^tm1Tew	B6.Cg-Ngf^tm1.1Blhe Sort1^tm1Tew	MGI:5461513

Genotype
MGI:3767628

hm1

• Allelic Composition: Sort1^tm1Tew/Sort1^tm1Tew
• Genetic Background: B6.129-Sort1^tm1Tew

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron morphology ( J:128451 )

• like wild-type neurons, cultured superior cervical ganglion neurons are resistant to apoptosis induced by pro-NGF and pro-BDNF

• however, pro-NGF and pro-BDNF induced apoptosis can be restored if neurons are treated with the intracellular domain of Ngfr

• sympathetic neurons survive the withdrawal of NGF better than wild-type neurons

• however, the number of sympathetic neurons is not increased

• unlike in wild-type mice, the number of superior cervical ganglion is not decreased at 60 weeks

abnormal motor neuron morphology ( J:128451 )

• unlike in wild-type mice, corticospinal motor neurons are protected from injury

abnormal retina ganglion cell morphology ( J:128451 )

• at E15.5, the number of apoptotic cells is reduced by 63% compared to in wild-type mice

vision/eye

abnormal retina ganglion cell morphology ( J:128451 )

• at E15.5, the number of apoptotic cells is reduced by 63% compared to in wild-type mice

Genotype
MGI:5461513

cx2

• Allelic Composition: Ngf^tm1.1Blhe/Ngf⁺; Sort1^tm1Tew/Sort1^tm1Tew
• Genetic Background: B6.Cg-Ngf^tm1.1Blhe Sort1^tm1Tew

mortality/aging

premature death ( J:190893 )

• most mice die by 4 months

• nearly all mice die by 8 months

cardiovascular system

dilated cardiomyopathy ( J:190893 )

muscle

dilated cardiomyopathy ( J:190893 )