All Phenotypes Bub1<tm1Ssta> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bub1^tm1Ssta/Bub1^tm1.1Ssta Tg(CAG-cre/Esr1*)5Amc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3767640
cn2	Bub1^tm1Ssta/Bub1^tm1Ssta Tg(CAG-cre/Esr1*)5Amc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3767641

Allelic Composition	Bub1^tm1Ssta/Bub1^tm1.1Ssta Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1^tm1.1Ssta mutation (0 available); any Bub1 mutation (52 available)
Bub1^tm1Ssta mutation (0 available); any Bub1 mutation (52 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:128455 )

• sister chromatid cohesion is defective in tamoxifen-treated mouse embryonic fibroblasts

abnormal mitotic spindle assembly checkpoint ( J:128455 )

• the spindle assembly checkpoint is defective in tamoxifen-treated mouse embryonic fibroblasts

decreased cell proliferation ( J:128455 )

• unlike untreated cells, tamoxifen-treated mouse embryonic fibroblasts stop proliferating in culture

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small seminiferous tubules ( J:128455 )

• after mice are treated with tamoxifen for 8 weeks, tubules exhibit decreased celullarity and diameter

• tubules containing only Sertoli cells are often observed

decreased testis weight ( J:128455 )

• after mice are treated with tamoxifen for 8 weeks, testis weight is decreased by 50% of wild-type

abnormal spermatogenesis ( J:128455 )

• after mice are treated with tamoxifen for 8 weeks, mitotic clusters of cells observed are often stuck in anaphase and abnormal chromosome content is observed

oligozoospermia ( J:128455 )

• after mice are treated with tamoxifen for 8 weeks, no male germ cells are observed

• after mice are treated with tamoxifen for 8 weeks, sperm production is reduced by 80% of wild-type

male infertility ( J:128455 )

• after treated with tamoxifen for 4 weeks, adult males become infertile

cellular

oligozoospermia ( J:128455 )

• after mice are treated with tamoxifen for 8 weeks, no male germ cells are observed

• after mice are treated with tamoxifen for 8 weeks, sperm production is reduced by 80% of wild-type

decreased mitotic index ( J:128455 )

• after mice are treated with tamoxifen for 8 weeks, male testes have reduced mitotic index

growth/size/body

decreased fetal size ( J:128455 )

• when mice are treated with tamoxifen beginning at E10.5, by E18.5 mice resemble E10.5 to E11.5 mice

fetal growth retardation ( J:128455 )