Phenotypes associated with this allele

• Allele Symbol: Bub1^tm1.1Ssta
• Allele Name: targeted mutation 1.1, Stephen S Taylor
• Allele ID: MGI:3767633
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bub1^tm1.1Ssta/Bub1^tm1.1Ssta	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3767639
cn2	Bub1^tm1Ssta/Bub1^tm1.1Ssta Tg(CAG-cre/Esr1*)5Amc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3767640

Genotype
MGI:3767639

hm1

• Allelic Composition: Bub1^tm1.1Ssta/Bub1^tm1.1Ssta
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:128455 )

• while embryos are present at E3.5 they exhibit no mitotic cells at E7.5 in culture

Genotype
MGI:3767640

cn2

• Allelic Composition: Bub1^tm1Ssta/Bub1^tm1.1Ssta; Tg(CAG-cre/Esr1*)5Amc/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

cellular

abnormal cell cycle ( J:128455 )

• sister chromatid cohesion is defective in tamoxifen-treated mouse embryonic fibroblasts

abnormal mitotic spindle assembly checkpoint ( J:128455 )

• the spindle assembly checkpoint is defective in tamoxifen-treated mouse embryonic fibroblasts

decreased cell proliferation ( J:128455 )

• unlike untreated cells, tamoxifen-treated mouse embryonic fibroblasts stop proliferating in culture