All Phenotypes Bub1<tm1.1Ssta> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bub1^tm1.1Ssta
targeted mutation 1.1, Stephen S Taylor
MGI:3767633

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bub1^tm1.1Ssta/Bub1^tm1.1Ssta	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3767639
cn2	Bub1^tm1Ssta/Bub1^tm1.1Ssta Tg(CAG-cre/Esr1*)5Amc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3767640

Allelic Composition	Bub1^tm1.1Ssta/Bub1^tm1.1Ssta
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1^tm1.1Ssta mutation (0 available); any Bub1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:128455 )

• while embryos are present at E3.5 they exhibit no mitotic cells at E7.5 in culture

Allelic Composition	Bub1^tm1Ssta/Bub1^tm1.1Ssta Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1^tm1.1Ssta mutation (0 available); any Bub1 mutation (52 available)
Bub1^tm1Ssta mutation (0 available); any Bub1 mutation (52 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:128455 )

• sister chromatid cohesion is defective in tamoxifen-treated mouse embryonic fibroblasts

abnormal mitotic spindle assembly checkpoint ( J:128455 )

• the spindle assembly checkpoint is defective in tamoxifen-treated mouse embryonic fibroblasts

decreased cell proliferation ( J:128455 )

• unlike untreated cells, tamoxifen-treated mouse embryonic fibroblasts stop proliferating in culture

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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