Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-STUB1)1Sobue
• Allele Name: transgene insertion 1, Gen Sobue
• Allele ID: MGI:3767714
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-AR*97Q)7-8Sobue/? Tg(CAG-STUB1)1Sobue/Tg(CAG-STUB1)1Sobue	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:3767787
cx2	Tg(CAG-AR*97Q)7-8Sobue/? Tg(CAG-STUB1)1Sobue/?	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:3767788
tg3	Tg(CAG-STUB1)1Sobue/Tg(CAG-STUB1)1Sobue	involves: C57BL/6 * DBA/2	MGI:3767786
tg4	Tg(CAG-STUB1)1Sobue/?	involves: C57BL/6 * DBA/2	MGI:3767785

Genotype
MGI:3767787

cx1

• Allelic Composition: Tg(CAG-AR*97Q)7-8Sobue/?; Tg(CAG-STUB1)1Sobue/Tg(CAG-STUB1)1Sobue
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:121559 )

• motor coordination impairment on a rotarod test is not as sever as in Tg(ACTB-AR*97Q)2-6Sobu male mice but not as improved as in Tg(ACTB-STUB1)Sobu/Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male mice

• male mice took smaller steps when walking than Tg(ACTB-STUB1)Sobu/Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male but longer than Tg(ACTB-AR*97Q)2-6Sobu male mice

muscle

muscular atrophy ( J:121559 )

• muscular atrophy in male mice is less than in Tg(ACTB-AR*97Q)2-6Sobu male mice

growth/size/body

weight loss ( J:121559 )

• male mice do not lose as much weight as quickly as Tg(ACTB-AR*97Q)2-6Sobu mice

Genotype
MGI:3767788

cx2

• Allelic Composition: Tg(CAG-AR*97Q)7-8Sobue/?; Tg(CAG-STUB1)1Sobue/?
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

behavior/neurological

impaired coordination ( J:121559 )

• motor coordination impairment on a rotarod test is not as sever as in Tg(ACTB-AR*97Q)2-6Sobu male mice or Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male mice and begins at 16 weeks

• however, mice walk normally

growth/size/body

weight loss ( J:121559 )

• male mice do not lose as much weight as quickly as Tg(ACTB-AR*97Q)2-6Sobu male mice

Genotype
MGI:3767786

tg3

• Allelic Composition: Tg(CAG-STUB1)1Sobue/Tg(CAG-STUB1)1Sobue
• Genetic Background: involves: C57BL/6 * DBA/2

behavior/neurological

behavior/neurological phenotype ( J:121559 )

N • male mice up to 50 weeks of age display no motor coordination impairments in a rotarod test

abnormal food intake ( J:121559 )

• male mice display a slight delay in weaning

muscle

muscle phenotype ( J:121559 )

N • male mice possess normal muscular structure

nervous system

nervous system phenotype ( J:121559 )

N • male mice display normal neuronal cell morphology and number

Genotype
MGI:3767785

tg4

• Allelic Composition: Tg(CAG-STUB1)1Sobue/?
• Genetic Background: involves: C57BL/6 * DBA/2

behavior/neurological

behavior/neurological phenotype ( J:121559 )

N • male mice up to 50 weeks of age display no motor coordination impairments in a rotarod test

abnormal food intake ( J:121559 )

• male mice display a slight delay in weaning

muscle

muscle phenotype ( J:121559 )

N • male mice possess normal muscular structure

nervous system

nervous system phenotype ( J:121559 )

N • male mice display normal neuronal cell morphology and number