Phenotypes associated with this allele

• Allele Symbol: Isl2^{tm3.1(Mnx1-Lhx3)Slp}
• Allele Name: targeted mutation 3.1, Samuel L Pfaff
• Allele ID: MGI:3767806
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Isl2^tm3.1(Mnx1-Lhx3)Slp/Isl2^+	Not Specified	MGI:3767808
cx2	Isl2^tm3.1(Mnx1-Lhx3)Slp/Isl2^+ Tg(Mnx1-GFP)1Slp/?	Not Specified	MGI:3767837

Genotype
MGI:3767808

ht1

• Allelic Composition: Isl2^{tm3.1(Mnx1-Lhx3)Slp}/Isl2⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:63774 )

• mice die at birth due to respiratory failure

nervous system

abnormal motor neuron morphology ( J:63774 )

• several markers of motor neurons are absent (Lhx4, Lhx1 and Er81) indicating that motor neurons have adopted a axial-innervating identity (medial half of median motor column)

• at E15.5, no Isl1+ cells in the intermediolateral position of the preganglionic motor column (PGC) motor neurons are detected in the thorax compared to 12+/-2 intermediolateral PGC cells in control mice

• fewer motor neurons project to their target

• lateral motor column (LMC) motor neurons fail to migrate from the ventral spinal cord to their normal intermediolateral position

abnormal motor neuron innervation pattern ( J:63774 )

• axial innervations are increased whereas limb innervations are decreased

abnormal axon morphology ( J:63774 , J:122940 )

• while axons arbourize extensively the ramus visceralis branch is nearly absent (J:63774)

• explants exhibit an increased in the number of axons attracted to the dermomyotome compared with explants from wild-type mice (J:122940)

respiratory system

respiratory failure ( J:63774 )

Genotype
MGI:3767837

cx2

• Allelic Composition: Isl2^{tm3.1(Mnx1-Lhx3)Slp}/Isl2⁺; Tg(Mnx1-GFP)1Slp/?
• Genetic Background: Not Specified

nervous system

abnormal motor neuron morphology ( J:122940 )

• the increased number of axons attracted to the dermomyotome is due to an increase in GFP+ neurons and not other neuronal types