Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Tek-Jam3)1Maal transgene insertion 1, Michel Aurrand-Lions MGI:3767832 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• percentage of mutants that survive to weaning is reduced (8.2% vs. the expected 12.5%)
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• about 65% of mutants develop hydrocephalus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Jam3tm1Rha homozygotes, mice do not exhibit any postnatal lethality due to housing conditions
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| N |
• unlike Jam3tm1Rha homozygotes, leukocyte homeostasis is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following injection of IL-1beta into the peritoneum to induce peritonitis, total leukocyte count is increased and there is a 3-fold increase in the percent of neutrophils that migrate into the peritoneal cavity compared to wild-type mice
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• 30 minutes after stimulation with LPS leukocytes accumulate in the vessels and airways in the lungs unlike in wild-type mice
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• following injection of IL-1beta into the peritoneum to induce peritonitis, the number of migrating neutrophils is increased 6-fold (2.44x106+/-1x106 compared to 0.382x106+/-0.124x106 in wild-type mice)
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• following injection of IL-1beta, leukocyte transmigration is increased 2-fold compared to in wild-type mice
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• following injection of IL-1beta, leukocyte adhesion is increased 2-fold compared to in wild-type mice
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• following intranasal LPS challenge, the number of granulocytes is increased by 4-fol and the number of inflammatory monocytes is increased by 2-fold in bronchoalveolar lavage fluid
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• following intranasal LPS challenge, the number of granulocytes is increased by 4-fol and the number of inflammatory monocytes is increased by 2-fold in bronchoalveolar lavage fluid
|
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• following injection of IL-1beta into the peritoneum to induce peritonitis, total leukocyte count is increased and there is a 3-fold increase in the percent of neutrophils that migrate into the peritoneal cavity compared to wild-type mice
|
|
• following injection of IL-1beta into the peritoneum to induce peritonitis, the number of migrating neutrophils is increased 6-fold (2.44x106+/-1x106 compared to 0.382x106+/-0.124x106 in wild-type mice)
|
|
• following injection of IL-1beta, leukocyte transmigration is increased 2-fold compared to in wild-type mice
|
|
• following injection of IL-1beta, leukocyte adhesion is increased 2-fold compared to in wild-type mice
|
|
• 30 minutes after stimulation with LPS leukocytes accumulate in the vessels and airways in the lungs unlike in wild-type mice
|
|
• following injection of IL-1beta into the peritoneum to induce peritonitis, the number of migrating neutrophils is increased 6-fold (2.44x106+/-1x106 compared to 0.382x106+/-0.124x106 in wild-type mice)
|
|
• following injection of IL-1beta, leukocyte transmigration is increased 2-fold compared to in wild-type mice
|
|
• following injection of IL-1beta, leukocyte adhesion is increased 2-fold compared to in wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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