Phenotypes associated with this allele

• Allele Symbol: Tg(Cd3d-Il5)NJ.1638Nal
• Allele Name: transgene insertion NJ.1638, Nancy A Lee
• Allele ID: MGI:3767981
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Cd3d-Il5)NJ.1638Nal/?	involves: C57BL/6J * CBA/J	MGI:3767988

Genotype
MGI:3767988

tg1

• Allelic Composition: Tg(Cd3d-Il5)NJ.1638Nal/?
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:123440 )

• 69% of mice die before a year of age with most exhibiting no overt morbidity prior to death

immune system

abnormal eosinophil differentiation ( J:123440 )

• numbers of more mature eosinophil-committed cell types are greatly increased in bone and spleen while numbers of uncommitted granulocytic precursors are similar to wild-type

peritoneal inflammation ( J:123440 )

• over 10⁸cells consisting of eosinophils and monocytes are found in the peritoneal cavity

abnormal T cell number ( J:123440 )

• larger number of T cells noted, though not as large as the increase in B cells

increased leukocyte cell number ( J:123440 )

• greater than 7-fold increase in white blood cells (WBC) per mm³ blood compared to non-transgenic controls

• by 15 months of age, WBC numbers are over 40 fold higher than in wild-type

• high levels of WBC are observed in newborn mice

increased eosinophil cell number ( J:123440 )

• the increase in WBC numbers is largely due to an increase in eosinophils which make up 47% of the WBC compared to 1% in wild-type mice

increased neutrophil cell number ( J:123440 )

• 3-10 fold increase in numbers though percentage of WBC is decreased

increased mature B cell number ( J:123440 )

• B cells dramatically increase with 4 fold greater numbers at 1 month of age, and 30 fold greater numbers by 12 months of age compared to age matched wild-type controls

• rate of B cell expansion is 4 times greater than T cell expansion

increased monocyte cell number ( J:123440 )

• 2-10 fold increase in numbers though percentage of WBC is decreased

abnormal spleen morphology ( J:123440 )

• characteristic architecture of the spleen is interrupted with mingling of red and white pulp areas

• in addition, white patches consisting mainly of eosinophils are found on the surface of the spleen

increased spleen weight ( J:123440 )

• spleens of 1 month old mice are 8 fold higher than wild-type controls

• spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls

enlarged lymph nodes ( J:123440 )

• 9% of mice exhibit enlarged lymph nodes, which can occur throughout the body

liver/biliary system

abnormal liver morphology ( J:123440 )

• eosinophils infiltrate the liver and form foci around hepatic blood vessels

increased liver weight ( J:123440 )

• by 7 months of age, weight of liver is 2 fold greater than in wild-type mice

digestive/alimentary system

rectal prolapse ( J:123440 )

• observed in 14% of transgenic mice over 1 year of age

peritoneal inflammation ( J:123440 )

• over 10⁸cells consisting of eosinophils and monocytes are found in the peritoneal cavity

cardiovascular system

enlarged heart ( J:123440 )

• postmortem examinations of some mice revealed enlarged hearts that were 2-3 fold larger than normal, with notable eosinophil infiltration

hematopoietic system

abnormal eosinophil differentiation ( J:123440 )

• numbers of more mature eosinophil-committed cell types are greatly increased in bone and spleen while numbers of uncommitted granulocytic precursors are similar to wild-type

erythroblastosis ( J:123440 )

• increase numbers of erythroblasts are found in spleen (14-fold) and liver

abnormal T cell number ( J:123440 )

• larger number of T cells noted, though not as large as the increase in B cells

increased leukocyte cell number ( J:123440 )

• greater than 7-fold increase in white blood cells (WBC) per mm³ blood compared to non-transgenic controls

• by 15 months of age, WBC numbers are over 40 fold higher than in wild-type

• high levels of WBC are observed in newborn mice

increased eosinophil cell number ( J:123440 )

• the increase in WBC numbers is largely due to an increase in eosinophils which make up 47% of the WBC compared to 1% in wild-type mice

increased neutrophil cell number ( J:123440 )

• 3-10 fold increase in numbers though percentage of WBC is decreased

increased mature B cell number ( J:123440 )

• B cells dramatically increase with 4 fold greater numbers at 1 month of age, and 30 fold greater numbers by 12 months of age compared to age matched wild-type controls

• rate of B cell expansion is 4 times greater than T cell expansion

increased monocyte cell number ( J:123440 )

• 2-10 fold increase in numbers though percentage of WBC is decreased

abnormal spleen morphology ( J:123440 )

• characteristic architecture of the spleen is interrupted with mingling of red and white pulp areas

• in addition, white patches consisting mainly of eosinophils are found on the surface of the spleen

increased spleen weight ( J:123440 )

• spleens of 1 month old mice are 8 fold higher than wild-type controls

• spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls

integument

alopecia ( J:123440 )

• some but not all transgenic mice exhibit alopecia and often precedes development of skin ulceration

spontaneous skin ulceration ( J:123440 )

• some but not all transgenic mice exhibit ulcerations with increased likelihood occurring with age

cellular

abnormal eosinophil differentiation ( J:123440 )

• numbers of more mature eosinophil-committed cell types are greatly increased in bone and spleen while numbers of uncommitted granulocytic precursors are similar to wild-type

growth/size/body

enlarged heart ( J:123440 )

• postmortem examinations of some mice revealed enlarged hearts that were 2-3 fold larger than normal, with notable eosinophil infiltration

increased liver weight ( J:123440 )

• by 7 months of age, weight of liver is 2 fold greater than in wild-type mice

increased spleen weight ( J:123440 )

• spleens of 1 month old mice are 8 fold higher than wild-type controls

• spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls spleen weight increases linearily with age so that by 10 months of age spleens are 24 fold higher than in wild-type controls