Phenotypes associated with this allele

• Allele Symbol: Tg(THY1-SNCA)1Sud
• Allele Name: transgene insertion 1, Thomas C Sudhof
• Allele ID: MGI:3767987
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dnajc5^tm1Sud/Dnajc5^tm1Sud Tg(THY1-SNCA)1Sud/0	involves: 129S6/SvEvTac * C57BL/6	MGI:3768117
cx2	Tg(SOD1*G93A)1Gur/0 Tg(THY1-SNCA)1Sud/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3768131
tg3	Tg(THY1-SNCA)1Sud/0	involves: C57BL/6	MGI:3768128

Genotype
MGI:3768117

cx1

• Allelic Composition: Dnajc5^tm1Sud/Dnajc5^tm1Sud; Tg(THY1-SNCA)1Sud/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:115193 )

N • double mutants show rescue of lethality observed for Dnajc5-deficient mice; mice live >15 months

behavior/neurological

behavior/neurological phenotype ( J:115193 )

N • transgenic Dnajc5-deficient mice have locomotor activity and righting ability like wild-type mice at all ages; ataxia is suppressed in mice

abnormal grip strength ( J:115193 )

• in a grip test, mice can grip the mesh for the 2 minute duration of the test up to 30 days of age; at this time point, their eyesight begins to deteriorate and performance starts to decline

nervous system

nervous system phenotype ( J:115193 )

N • gliosis and neuron degeneration observed in Dnajc5-null mice are rescued by transgene expression

retina photoreceptor degeneration ( J:115193 )

• mice show considerable photoreceptor degeneration

vision/eye

retina photoreceptor degeneration ( J:115193 )

• mice show considerable photoreceptor degeneration

abnormal vision ( J:115193 )

Genotype
MGI:3768131

cx2

• Allelic Composition: Tg(SOD1*G93A)1Gur/0; Tg(THY1-SNCA)1Sud/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

nervous system

neurodegeneration ( J:115193 )

• mice display neurodegeneration similar to Dnajc5-null mice

Genotype
MGI:3768128

tg3

• Allelic Composition: Tg(THY1-SNCA)1Sud/0
• Genetic Background: involves: C57BL/6

nervous system

decreased motor neuron number ( J:115193 )

• at 12-16 months, mice have only ~40% of motor neuron numbers in non-transgenic mice

motor neuron degeneration ( J:115193 )

• mice show onset of motoneuron disease at ~5-6 months