Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(APOE_i3*,APOC1)2Lmh transgene insertion 2, Louis M Havekes MGI:3768068 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• larger plaques made up of smooth muscle and foam cells when treated with lipopolysaccharide and on a high fat diet
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• increased thickness of external elastic lamina after 3 weeks of treatment with lipopolysaccharide when on a high fat diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females develop atherosclerotic lesions after 20 weeks on Western diet
• phenotype is less severe than in transgenic Tg(Alb-MYLIP*)1Pton mice
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• increased plasma cholesterol levels after 20 weeks on western diet
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• LDL cholesterol levels are increased after 20 weeks on western diet as compared to wild-type
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• increased VLDL cholesterol levels after 20 weeks on western diet
• VLDL fraction is higher than the level observed in transgenic Tg(Alb-MYLIP*)1Pton mice, although total cholesterol and LDL fractions are similar
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• increased plasma triglyceride levels after 20-30 weeks on western diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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