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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APOE_i3*,APOC1)2Lmh
transgene insertion 2, Louis M Havekes
MGI:3768068
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(APOE_i3*,APOC1)2Lmh/? B6.Cg-Tg(APOE*3,APOC1)2Lmh MGI:4412007
tg2
Tg(APOE_i3*,APOC1)2Lmh/? involves: C57BL/6J * CBA MGI:5707296


Genotype
MGI:4412007
tg1
Allelic
Composition
Tg(APOE_i3*,APOC1)2Lmh/?
Genetic
Background
B6.Cg-Tg(APOE*3,APOC1)2Lmh
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• larger plaques made up of smooth muscle and foam cells when treated with lipopolysaccharide and on a high fat diet
• increased thickness of external elastic lamina after 3 weeks of treatment with lipopolysaccharide when on a high fat diet




Genotype
MGI:5707296
tg2
Allelic
Composition
Tg(APOE_i3*,APOC1)2Lmh/?
Genetic
Background
involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• females develop atherosclerotic lesions after 20 weeks on Western diet
• phenotype is less severe than in transgenic Tg(Alb-MYLIP*)1Pton mice

homeostasis/metabolism
• increased plasma cholesterol levels after 20 weeks on western diet
• LDL cholesterol levels are increased after 20 weeks on western diet as compared to wild-type
• increased VLDL cholesterol levels after 20 weeks on western diet
• VLDL fraction is higher than the level observed in transgenic Tg(Alb-MYLIP*)1Pton mice, although total cholesterol and LDL fractions are similar
• increased plasma triglyceride levels after 20-30 weeks on western diet





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory