Phenotypes associated with this allele

• Allele Symbol: Nanos2^tm3Ysa
• Allele Name: targeted mutation 3, Yumiko Saga
• Allele ID: MGI:3768177
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nanos2^tm3Ysa/Nanos2^tm3Ysa	involves: C57BL/6 * CBA * ICR	MGI:3768233
ht2	Nanos2^tm1Ysa/Nanos2^tm3Ysa	involves: 129 * C57BL/6 * CBA * ICR	MGI:3768235

Genotype
MGI:3768233

hm1

• Allelic Composition: Nanos2^tm3Ysa/Nanos2^tm3Ysa
• Genetic Background: involves: C57BL/6 * CBA * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased male germ cell number ( J:119032 )

♂ • while germ cell number is normal at E18.5, the number of male germ cells decreases transiently 2 weeks after birth

♂ • however, the deficiency in male germ cells is recovered by 6 weeks and no fertility defects are observed

abnormal seminiferous tubule morphology ( J:119032 )

♂ • at 2 weeks, unlike in wild-type mice three different types of seminiferous tubule morphologies are observed, namely: ones with few spermatogonia, ones with more spermatogonia localized to the periphery and ones with few spermatocytes in addition to spermatogonia

abnormal spermatogenesis ( J:119032 )

♂ • 1 week after birth, the number of cells undergoing apoptosis in the testes is increased compared to in wild-type mice

♂ • however, apoptosis rates in the testes are comparable to wild-type by 3 weeks of age

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:119032 )

♂ • at 2 weeks, unlike in wild-type mice three different types of seminiferous tubule morphologies are observed, namely: ones with few spermatogonia, ones with more spermatogonia localized to the periphery and ones with few spermatocytes in addition to spermatogonia

cellular

decreased male germ cell number ( J:119032 )

♂ • while germ cell number is normal at E18.5, the number of male germ cells decreases transiently 2 weeks after birth

♂ • however, the deficiency in male germ cells is recovered by 6 weeks and no fertility defects are observed

Genotype
MGI:3768235

ht2

• Allelic Composition: Nanos2^tm1Ysa/Nanos2^tm3Ysa
• Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

reproductive system

decreased male germ cell number ( J:119032 )

♂ • at E18.5, the number of male germ cells is reduced, continues to be after birth and does not recover until 5 months of age

abnormal seminiferous tubule morphology ( J:119032 )

♂ • at 2 and 6 weeks, unlike in wild-type mice three different types of seminiferous tubule morphologies are observed, namely: ones with few spermatogonia, ones with more spermatogonia localized to the periphery and ones with few spermatocytes in addition to spermatogonia

abnormal spermatogenesis ( J:119032 )

♂ • at E18.5, some germ cells are localized outside of the testis cord

♂ • at E18.5 and 1 week after birth, the number of cells undergoing apoptosis in the testes is increased compared to in wild-type mice

♂ • however, apoptosis rates in the testes are comparable to wild-type by 3 weeks of age

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:119032 )

♂ • at 2 and 6 weeks, unlike in wild-type mice three different types of seminiferous tubule morphologies are observed, namely: ones with few spermatogonia, ones with more spermatogonia localized to the periphery and ones with few spermatocytes in addition to spermatogonia

cellular

decreased male germ cell number ( J:119032 )

♂ • at E18.5, the number of male germ cells is reduced, continues to be after birth and does not recover until 5 months of age