Phenotypes associated with this allele

• Allele Symbol: Jsrp1^tm1Zor
• Allele Name: targeted mutation 1, Francesco Zorzato
• Allele ID: MGI:3768247
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jsrp1^tm1Zor/Jsrp1^tm1Zor	involves: 129S4/SvJae * C57BL/6	MGI:3768251

Genotype
MGI:3768251

hm1

• Allelic Composition: Jsrp1^tm1Zor/Jsrp1^tm1Zor
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle physiology ( J:128603 )

• extensor digitorum longus (EDL) and soleus muscles display reduced twitch and maximal titanic absolute force compared to wild-type

• the muscle specific force is impaired

• EDL maximal tetani is 25% lower than in wild-type mice (287+/-38.6 mN per mm² compared to 381+/-46.7 mN per mm² in wild-type mice)

• the maximal titanic force is reduced in the solei (244+/-41.6 compared to 301+/-46.7 in wild-type mice)

• however, there are no alterations in contraction and relaxation kinetics, muscle structure or fast-to-slow fiber transition

muscle weakness ( J:128603 )

• skeletal muscle strength is decreased 20% to 30%

homeostasis/metabolism

impaired exercise endurance ( J:128603 )

• in a voluntary running wheel set-up, mice run less than wild-type in terms of total distance covered and median cruise speed is lower than in wild-type mice

behavior/neurological

impaired exercise endurance ( J:128603 )

• in a voluntary running wheel set-up, mice run less than wild-type in terms of total distance covered and median cruise speed is lower than in wild-type mice