Phenotypes associated with this allele

• Allele Symbol: Scn1b^tm2.1Isom
• Allele Name: targeted mutation 2.1, Lori L Isom
• Allele ID: MGI:3768514
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn1b^tm2.1Isom/Scn1b^tm2.1Isom	involves: 129X1/SvJ * C57BL/6	MGI:3768515

Genotype
MGI:3768515

hm1

• Allelic Composition: Scn1b^tm2.1Isom/Scn1b^tm2.1Isom
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:128713 )

• phenotype was indistinguishable from homozygous Scn1b^tm1Isom mice

• 100% lethality occurs by 3 weeks of age

behavior/neurological

ataxia ( J:128713 )

• is observed in all mice

seizures ( J:128713 )

• severe seizures begin occurring at postnatal day 10

growth/size/body

postnatal growth retardation ( J:128713 )

• mice are half the weight of their wild-type littermates by day 17 post-birth

nervous system

seizures ( J:128713 )

• severe seizures begin occurring at postnatal day 10