Analysis Tools
mortality/aging
|
• all homozygous mice died by 11-13 months of age
• direct cause of death could not determined
|
behavior/neurological
limb grasping
(
J:96869
)
|
• less severe clasping of limbs in old (9-12 months) mice when lifted by the tail showing only partial retraction and still spreading toes
|
|
• most homozygous mice showed moderate to severe decline in ambulation in the home cage by age 9-10 months
• only some of oldest mice revealed a motor deficit on beam walk test
|
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• paralysis progressed to include the forelimbs with age in all animal by age 9-10 months
|
|
• minor paresis of the hind limbs in some mice at 6 months
• no motor problems before age 6 months
|
growth/size/body
weight loss
(
J:96869
)
|
• due to muscle and tissue wasting by 9-10 months
|
nervous system
| N |
• axonal dilations were completely absent in brain and spinal cord at any age
|
|
• neurofibrillary pathology was evident in all old mice by silver impregnation and fluorescent staining with thioflavin S and X-34
• positive tauopathy was observed in brain and spinal cord neurons
|
|
• fraction of neuronal tau in aging mice was hyper phosphorylated concomitant with conformational changes and aggregation co-localizing in the same neurons
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:96869 | ||
