Phenotypes associated with this allele

• Allele Symbol: Mapt^tm1(MAPT)Vln
• Allele Name: targeted mutation 1, Fred Van Leuven
• Allele ID: MGI:3768527
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapt^tm1(MAPT)Vln/Mapt^tm1(MAPT)Vln	FVB.Cg-Mapt^tm1(MAPT)Vln	MGI:3771318
hm2	Mapt^tm1(MAPT)Vln/Mapt^tm1(MAPT)Vln	involves: FVB/N	MGI:3770441

Genotype
MGI:3771318

hm1

• Allelic Composition: Mapt^tm1(MAPT)Vln/Mapt^tm1(MAPT)Vln
• Genetic Background: FVB.Cg-Mapt^tm1(MAPT)Vln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:96869 )

• a motor deficit on beam walk test in all mice by 9-12 moths

• impaired in rotarod performance by age 9-10 months

• homozygous mice are indistinguishable from wild-type mice until 6 months old

• no clasping of limbs

nervous system

nervous system phenotype ( J:96869 )

N • axonal dilations were completely absent in brain and spinal cord at any age

N • reaction with thioflavin S or X-34 was completely absent confirming the total absence of tauopathy

Genotype
MGI:3770441

hm2

• Allelic Composition: Mapt^tm1(MAPT)Vln/Mapt^tm1(MAPT)Vln
• Genetic Background: involves: FVB/N

nervous system

abnormal axon extension ( J:129032 )

• in culture, hippocampal cells exhibit less neurite outgrowth than wild-type cells

abnormal hippocampus pyramidal cell morphology ( J:129032 )

• the volume increase in CA1 parallels the increase in CA1 pyramidal cells

enlarged hippocampus ( J:129032 )

• in adult mice, hippocampal volume and neuron number is increased by 20% compared to in wild-type mice

• the volume increase in CA1 parallels the increase in CA1 pyramidal cells

• cells proliferation within the hippocampus is increased

abnormal dendrite morphology ( J:129032 )

• hippocampal cell dendrite length is decreased compared to wild-type

behavior/neurological

enhanced long-term object recognition memory ( J:129032 )

• mice exhibit increased memory retention compared to wild-type mice

decreased anxiety-related response ( J:129032 )

• mice spend more time in the center of an open field test than wild-type mice

cellular

abnormal axon extension ( J:129032 )

• in culture, hippocampal cells exhibit less neurite outgrowth than wild-type cells

increased cell proliferation ( J:129032 )

• when hippocampal cells are grown in culture, proliferation and differentiation into neural phenotypes in greater than in cultures of wild-type cells