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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat3tm1Xyfu
targeted mutation 1, Xin-Yuan Fu
MGI:3768531
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Stat3tm1Xyfu/Stat3+ involves: 129S1/Sv * C57BL/6 MGI:3768556
cn2
 		Ptpn11tm1Gsf/Ptpn11tm1Gsf
Stat3tm1Xyfu/Stat3tm1Xyfu
Tg(Six3-cre)69Frty/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:6384015
cn3
 		Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Ttr-cre)10-3Xyfu/? 		involves: 129S1/Sv * C57BL/6 MGI:3768557
cn4
 		Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Myh6-cre)2182Mds/0 		involves: 129S1/Sv * FVB/N MGI:4879018
cn5
 		Stat3tm1Xyfu/Stat3+
Tg(Myh6-cre)2182Mds/0 		involves: 129S1/Sv * FVB/N MGI:4879021


Genotype
MGI:3768556
ht1
Allelic
Composition		 Stat3tm1Xyfu/Stat3+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:128719 )
• mortality during the first 12 hours following 70% hepatectomy is 5.5%




Genotype
MGI:6384015
cn2
Allelic
Composition		 Ptpn11tm1Gsf/Ptpn11tm1Gsf
Stat3tm1Xyfu/Stat3tm1Xyfu
Tg(Six3-cre)69Frty/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Gsf mutation (0 available); any Ptpn11 mutation (46 available)
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
Tg(Six3-cre)69Frty mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina ganglion cell degeneration ( J:174095 )
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele
thin retina ganglion layer ( J:174095 )
• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele
thin retina inner nuclear layer ( J:174095 )
• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele
thin retina outer nuclear layer ( J:174095 )
• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele
retina outer nuclear layer degeneration ( J:174095 )
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele
thin retina outer plexiform layer ( J:174095 )
• largely disappeared at age P21, more severe than in mice with wildtype Stat3 allele
retina degeneration ( J:174095 )
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele

nervous system
retina ganglion cell degeneration ( J:174095 )
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele




Genotype
MGI:3768557
cn3
Allelic
Composition		 Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Ttr-cre)10-3Xyfu/?
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1.1Xyfu mutation (0 available); any Stat3 mutation (72 available)
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
Tg(Ttr-cre)10-3Xyfu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:128719 )
• mortality during the first 12 hours following a 70% hepatectomy is 35.3% compared to 5.5% in Stat3tm1Xyfu homozygotes
• however, mortality rates after 72 hours are similar

liver/biliary system
decreased hepatocyte proliferation ( J:128719 )
• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3tm1Xyfu homozygotes
• however, liver regeneration following hepatectomy is completed

immune system
increased neutrophil cell number ( J:128719 )
• following carbon tetrachloride injection
increased monocyte cell number ( J:128719 )
• following carbon tetrachloride injection

hematopoietic system
increased neutrophil cell number ( J:128719 )
• following carbon tetrachloride injection
increased monocyte cell number ( J:128719 )
• following carbon tetrachloride injection

cellular
decreased hepatocyte proliferation ( J:128719 )
• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3tm1Xyfu homozygotes
• however, liver regeneration following hepatectomy is completed




Genotype
MGI:4879018
cn4
Allelic
Composition		 Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1.1Xyfu mutation (0 available); any Stat3 mutation (72 available)
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:86400 )
• after 6 months of age
increased heart left ventricle size ( J:86400 )
• at 200 days, mice exhibit increased left ventricular chamber size compared with wild-type mice
cardiac fibrosis ( J:86400 )
• mild at 6 months
• severe at 9 months
dilated heart ( J:86400 )
• after 6 months of age
abnormal cardiovascular system physiology ( J:86400 )
• doxorubicin-treated mice exhibit a greater decrease in cardiac systolic function compared with similarly treated wild-type mice
congestive heart failure ( J:86400 )
• after 6 months of age

immune system
increased tumor necrosis factor secretion ( J:86400 )
• in the cardiac myocytes of LPS-treated mice
increased susceptibility to endotoxin shock ( J:86400 )
• LPS-treated mice exhibit increased myocyte apoptosis and TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice

homeostasis/metabolism
ascites ( J:86400 )
• after 6 months of age
increased physiological sensitivity to xenobiotic ( J:86400 )
• doxorubicin-treated mice exhibit a greater decrease in cardiac systolic function compared with similarly treated wild-type mice

respiratory system
respiratory distress ( J:86400 )
• after 6 months of age

growth/size/body
enlarged heart ( J:86400 )
• after 6 months of age
cachexia ( J:86400 )
• after 6 months of age

muscle
increased cardiomyocyte apoptosis ( J:86400 )
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice

cellular
increased cardiomyocyte apoptosis ( J:86400 )
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice




Genotype
MGI:4879021
cn5
Allelic
Composition		 Stat3tm1Xyfu/Stat3+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased tumor necrosis factor secretion ( J:86400 )
• in the cardiac myocytes of LPS-treated mice
increased susceptibility to endotoxin shock ( J:86400 )
• LPS-treated mice exhibit increased TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice although not as severely as in homozygous mice

cardiovascular system
cardiac fibrosis ( J:86400 )
• severe at 9 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory