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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat3tm1.1Xyfu
targeted mutation 1.1, Xin-Yuan Fu
MGI:3768533
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Ttr-cre)10-3Xyfu/? 		involves: 129S1/Sv * C57BL/6 MGI:3768557
cn2
 		Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Myh6-cre)2182Mds/0 		involves: 129S1/Sv * FVB/N MGI:4879018


Genotype
MGI:3768557
cn1
Allelic
Composition		 Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Ttr-cre)10-3Xyfu/?
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1.1Xyfu mutation (0 available); any Stat3 mutation (72 available)
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
Tg(Ttr-cre)10-3Xyfu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:128719 )
• however, mortality rates after 72 hours are similar
• mortality during the first 12 hours following a 70% hepatectomy is 35.3% compared to 5.5% in Stat3tm1Xyfu homozygotes

liver/biliary system
decreased hepatocyte proliferation ( J:128719 )
• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3tm1Xyfu homozygotes
• however, liver regeneration following hepatectomy is completed

immune system
increased neutrophil cell number ( J:128719 )
• following carbon tetrachloride injection
increased monocyte cell number ( J:128719 )
• following carbon tetrachloride injection

hematopoietic system
increased neutrophil cell number ( J:128719 )
• following carbon tetrachloride injection
increased monocyte cell number ( J:128719 )
• following carbon tetrachloride injection

cellular
decreased hepatocyte proliferation ( J:128719 )
• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3tm1Xyfu homozygotes
• however, liver regeneration following hepatectomy is completed




Genotype
MGI:4879018
cn2
Allelic
Composition		 Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1.1Xyfu mutation (0 available); any Stat3 mutation (72 available)
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:86400 )
• after 6 months of age
increased heart left ventricle size ( J:86400 )
• at 200 days, mice exhibit increased left ventricular chamber size compared with wild-type mice
cardiac fibrosis ( J:86400 )
• mild at 6 months
• severe at 9 months
dilated heart ( J:86400 )
• after 6 months of age
abnormal cardiovascular system physiology ( J:86400 )
• doxorubicin-treated mice exhibit a greater decrease in cardiac systolic function compared with similarly treated wild-type mice
congestive heart failure ( J:86400 )
• after 6 months of age

immune system
increased tumor necrosis factor secretion ( J:86400 )
• in the cardiac myocytes of LPS-treated mice
increased susceptibility to endotoxin shock ( J:86400 )
• LPS-treated mice exhibit increased myocyte apoptosis and TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice

homeostasis/metabolism
ascites ( J:86400 )
• after 6 months of age
increased physiological sensitivity to xenobiotic ( J:86400 )
• doxorubicin-treated mice exhibit a greater decrease in cardiac systolic function compared with similarly treated wild-type mice

respiratory system
respiratory distress ( J:86400 )
• after 6 months of age

growth/size/body
enlarged heart ( J:86400 )
• after 6 months of age
cachexia ( J:86400 )
• after 6 months of age

muscle
increased cardiomyocyte apoptosis ( J:86400 )
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice

cellular
increased cardiomyocyte apoptosis ( J:86400 )
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory