Phenotypes associated with this allele

• Allele Symbol: Chn1^tm2Abet
• Allele Name: targeted mutation 2, Andrea Betz
• Allele ID: MGI:3768538
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chn1^tm2Abet/Chn1^tm2Abet	involves: 129P2/OlaHsd * FVB/N	MGI:3768544

Genotype
MGI:3768544

hm1

• Allelic Composition: Chn1^tm2Abet/Chn1^tm2Abet
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

tonic seizures ( J:128724 )

abnormal axon extension ( J:128724 )

• fewer growth cones collapse in culture when neurons are treated with Efnb3 or Efna1 compared to in wild-type cultures

enlarged brain ventricles ( J:128724 )

• some ventricles are enlarged

behavior/neurological

abnormal gait ( J:128724 )

• at the onset of locomotion mice display a rabbit-like hopping gait

tonic seizures ( J:128724 )

growth/size/body

decreased body size ( J:128724 )

• shortly after birth mice are smaller than wild-type but reach normal size by adulthood

cellular

abnormal axon extension ( J:128724 )

• fewer growth cones collapse in culture when neurons are treated with Efnb3 or Efna1 compared to in wild-type cultures