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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Osr2tm2(cre)Jian
targeted mutation 2, Rulang Jiang
MGI:3768549
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Osr2tm2(cre)Jian/Osr2+ involves: 129S1/Sv * C57BL/6 MGI:3768550
cn2
 		Gsk3btm1.1Ypc/Gsk3btm1.1Ypc
Osr2tm2(cre)Jian/Osr2+ 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:4867293
cn3
 		Hand2tm1Cse/Hand2tm1Cse
Osr2tm2(cre)Jian/Osr2+ 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3848961
cn4
 		Osr2tm2(cre)Jian/Osr2+
Tg(CAG-Nog)1Ych/0 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3848966
cn5
 		Ctnnb1tm2Kem/Ctnnb1+
Osr2tm2(cre)Jian/Osr2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:4365782
cn6
 		Ctnnb1tm2Kem/Ctnnb1tm2Kem
Osr2tm2(cre)Jian/Osr2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5003151
cn7
 		Mapk1tm1Gela/Mapk1tm1Gela
Osr2tm2(cre)Jian/Osr2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5902465
cn8
 		Osr2tm2(cre)Jian/Osr2+
Tg(CAG-Bmp4,-EGFP)1Ypc/0 		involves: 129S1/Sv * C57BL/6J * CD-1 MGI:6110830


Genotype
MGI:3768550
ht1
Allelic
Composition		 Osr2tm2(cre)Jian/Osr2+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:128736 )
• mice do not display any obvious defects




Genotype
MGI:4867293
cn2
Allelic
Composition		 Gsk3btm1.1Ypc/Gsk3btm1.1Ypc
Osr2tm2(cre)Jian/Osr2+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1.1Ypc mutation (0 available); any Gsk3b mutation (113 available)
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:166721 )
N
• unlike germline null mice, mice survive postnatally

craniofacial
craniofacial phenotype ( J:166721 )
N
• unlike in germline null mice, palate formation is normal




Genotype
MGI:3848961
cn3
Allelic
Composition		 Hand2tm1Cse/Hand2tm1Cse
Osr2tm2(cre)Jian/Osr2+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Cse mutation (0 available); any Hand2 mutation (12 available)
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
mandible hypoplasia ( J:149232 )
• mandible is hypoplastic
• cleft palate is not observed

skeleton
mandible hypoplasia ( J:149232 )
• mandible is hypoplastic
• cleft palate is not observed




Genotype
MGI:3848966
cn4
Allelic
Composition		 Osr2tm2(cre)Jian/Osr2+
Tg(CAG-Nog)1Ych/0
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
Tg(CAG-Nog)1Ych mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

skeleton

digestive/alimentary system

growth/size/body
cleft palate ( J:149232 )




Genotype
MGI:4365782
cn5
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1+
Osr2tm2(cre)Jian/Osr2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal enamel knot morphology ( J:153554 )
• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5
• however, no increase in cell death in tooth epithelium and mesenchyme is detected
growth retardation of incisors ( J:153554 )
• incisor development arrests at bud stage
growth retardation of molars ( J:153554 )
• molar development arrests at bud stage

mortality/aging

craniofacial
abnormal enamel knot morphology ( J:153554 )
• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5
• however, no increase in cell death in tooth epithelium and mesenchyme is detected
growth retardation of incisors ( J:153554 )
• incisor development arrests at bud stage
growth retardation of molars ( J:153554 )
• molar development arrests at bud stage

digestive/alimentary system

growth/size/body
abnormal enamel knot morphology ( J:153554 )
• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5
• however, no increase in cell death in tooth epithelium and mesenchyme is detected
growth retardation of incisors ( J:153554 )
• incisor development arrests at bud stage
growth retardation of molars ( J:153554 )
• molar development arrests at bud stage
cleft secondary palate ( J:153554 )




Genotype
MGI:5003151
cn6
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Osr2tm2(cre)Jian/Osr2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal joint morphology ( J:171478 )
• at E13.5, joints are not as clearly organized as in wild-type mice




Genotype
MGI:5902465
cn7
Allelic
Composition		 Mapk1tm1Gela/Mapk1tm1Gela
Osr2tm2(cre)Jian/Osr2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Gela mutation (1 available); any Mapk1 mutation (43 available)
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:239772 )
N
• newborns do not exhibit cleft palate and tongues and mandibles are unaffected




Genotype
MGI:6110830
cn8
Allelic
Composition		 Osr2tm2(cre)Jian/Osr2+
Tg(CAG-Bmp4,-EGFP)1Ypc/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm2(cre)Jian mutation (1 available); any Osr2 mutation (18 available)
Tg(CAG-Bmp4,-EGFP)1Ypc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
palatal shelves fail to meet at midline ( J:214763 )
• at the anterior level, the palatal shelves elevate but fail to contact
• however, origin of palatal shelves form the maxillary processes remains unaltered
palatal shelf fusion with tongue or mandible ( J:214763 )
• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

digestive/alimentary system
palatal shelves fail to meet at midline ( J:214763 )
• at the anterior level, the palatal shelves elevate but fail to contact
• however, origin of palatal shelves form the maxillary processes remains unaltered
palatal shelf fusion with tongue or mandible ( J:214763 )
• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

growth/size/body
palatal shelves fail to meet at midline ( J:214763 )
• at the anterior level, the palatal shelves elevate but fail to contact
• however, origin of palatal shelves form the maxillary processes remains unaltered
palatal shelf fusion with tongue or mandible ( J:214763 )
• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible
cleft palate ( J:214763 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory