Analysis Tools
nervous system
|
• TH+ neurons in the substantia nigra, ventral tegmental area and the locus coeruleus exhibit an age-dependent loss
• the number of TH+ neurons is slightly lower than in wild-type mice
|
|
• the input resistance in the striatal motorsensory neurons is smaller than wild-type mice
|
|
• mice exhibit a 4% reduction in TH+ neurons when treated with the dopamine neurotoxin MPTP compared to 27% in wild-type mice
|
|
• the paired pulse ratio following treatment with nomiferensine (a selective dopamine re-uptake inhibitor) is decreased whereas it is slightly increased in wild-type mice
|
|
• the inhibitory postsynaptic current is decreased when stimulated at low frequency before and after treatment with nomiferensine compared to in wild-type mice
|
behavior/neurological
|
• initial locomotor activity is lower than in wild-type mice but unlike in wild-type mice activity does not decrease following habituation
|
homeostasis/metabolism
|
• mice exhibit a 4% reduction in TH+ neurons when treated with the dopamine neurotoxin MPTP compared to 27% in wild-type mice
|
|
• dopamine levels in the striatum are decreased 60% of wild-type
|
cellular
|
• mice exhibit a 4% reduction in TH+ neurons when treated with the dopamine neurotoxin MPTP compared to 27% in wild-type mice
|
