Phenotypes associated with this allele

• Allele Symbol: Tg(PDGFB-GPR37)20Ryot
• Allele Name: transgene insertion 20, Ryosuke Takahashi
• Allele ID: MGI:3768633
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prkn^tm1Ykt/Prkn^tm1Ykt Tg(PDGFB-GPR37)20Ryot/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3814328
cx2	Prkn^tm1Ykt/Prkn^tm1Ykt Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot	involves: 129P2/OlaHsd * C57BL/6	MGI:3814330
tg3	Tg(PDGFB-GPR37)20Ryot/0	involves: C57BL/6	MGI:3768657

Genotype
MGI:3814328

cx1

• Allelic Composition: Prkn^tm1Ykt/Prkn^tm1Ykt; Tg(PDGFB-GPR37)20Ryot/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

neuron degeneration ( J:140326 )

• at 18 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological

behavior/neurological phenotype ( J:140326 )

N • mice exhibit normal behaviors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 2		DOID:0060368	OMIM:600116	J:140326

Genotype
MGI:3814330

cx2

• Allelic Composition: Prkn^tm1Ykt/Prkn^tm1Ykt; Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

neuron degeneration ( J:140326 )

• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological

behavior/neurological phenotype ( J:140326 )

N • mice exhibit normal behaviors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 2		DOID:0060368	OMIM:600116	J:140326

Genotype
MGI:3768657

tg3

• Allelic Composition: Tg(PDGFB-GPR37)20Ryot/0
• Genetic Background: involves: C57BL/6

nervous system

nervous system phenotype ( J:140326 )

N • unlike other transgene lines over-expressing GPR37, mice do not exhibit dopaminergic neuron loss

behavior/neurological

hyperactivity ( J:128745 )

homeostasis/metabolism

increased dopamine level ( J:128745 )

• DOPAC and vesicular dopamine levels are increased in the striatum compared to in wild-type mice