Phenotypes associated with this allele

• Allele Symbol: Cd79b^tm3Mnz
• Allele Name: targeted mutation 3, Michel C Nussenzweig
• Allele ID: MGI:3768659
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79b^tm3Mnz/Cd79b^tm3Mnz	involves: 129/Sv * C57BL/6	MGI:3768662
cx2	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm3Mnz/Cd79b^tm3Mnz	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3768661

Genotype
MGI:3768662

hm1

• Allelic Composition: Cd79b^tm3Mnz/Cd79b^tm3Mnz
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immature B cell morphology ( J:128768 )

• immature B cells produce less surface IgM and IgD than wild-type

decreased immature B cell number ( J:128768 )

• the number of IgM+B220^lowIgD^-/low immature B cells is reduced compared to wild-type

increased pro-B cell number ( J:128768 )

• the number of IgM-B220^lowCD43+ pro-B cells is increased compared to wild-type

increased marginal zone B cell number ( J:128768 )

• small increase

decreased B cell number ( J:128768 )

• the number of B220+IgM+ B cells in the spleen is decreased by 30% of wild-type

decreased mature B cell number ( J:128768 )

• the number of circulating mature IgM+B220^high B cells is slightly reduced (4% compared to 12% in wild-type mice)

decreased B-1a cell number ( J:128768 )

• the number of B1a B cells in the peritoneum is decreased 7-fold compared to wild-type

abnormal immune system physiology ( J:128768 )

• mice exhibit a 3- to 5-fold reduction in IgM and IgG response to T-dependent antigens such as NP-CGG and NP-Ficoll compared to wild-type mice

• despite normal levels of surface Cd40lg and Cd180, mice fail to response to Cd40lg, Cd180, CpG and LPS stimulation

• cell division in response to Cd40lg and Cd180 stimulation less and fewer cells are induced to divide in response to LPS and CpG stimulation compared to wild-type

abnormal B cell physiology ( J:128768 )

• the half-life of B cells in the spleen is increased (58.3 days compared to 23.4 days for wild-type)

decreased B cell proliferation ( J:128768 )

• B cells fail to proliferate in response to BCR cross-linking as wild-type mice do

hematopoietic system

abnormal immature B cell morphology ( J:128768 )

• immature B cells produce less surface IgM and IgD than wild-type

decreased immature B cell number ( J:128768 )

• the number of IgM+B220^lowIgD^-/low immature B cells is reduced compared to wild-type

increased pro-B cell number ( J:128768 )

• the number of IgM-B220^lowCD43+ pro-B cells is increased compared to wild-type

increased marginal zone B cell number ( J:128768 )

• small increase

decreased B cell number ( J:128768 )

• the number of B220+IgM+ B cells in the spleen is decreased by 30% of wild-type

decreased mature B cell number ( J:128768 )

• the number of circulating mature IgM+B220^high B cells is slightly reduced (4% compared to 12% in wild-type mice)

decreased B-1a cell number ( J:128768 )

• the number of B1a B cells in the peritoneum is decreased 7-fold compared to wild-type

abnormal B cell physiology ( J:128768 )

• the half-life of B cells in the spleen is increased (58.3 days compared to 23.4 days for wild-type)

decreased B cell proliferation ( J:128768 )

• B cells fail to proliferate in response to BCR cross-linking as wild-type mice do

cellular

decreased B cell proliferation ( J:128768 )

• B cells fail to proliferate in response to BCR cross-linking as wild-type mice do

Genotype
MGI:3768661

cx2

• Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn; Cd79b^tm3Mnz/Cd79b^tm3Mnz
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

immune system

immune system phenotype ( J:128768 )

N • unlike in Cd79b^tm3Mnz homozygotes, B cells proliferate in response to BCR cross-linking