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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Frs2tm1Fwan
targeted mutation 1, Fen Wang
MGI:3768912
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Frs2tm1Fwan/Frs2tm1Fwan
Nkx2-5tm1(cre)Rjs/? 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3768916
cn2
 		Foxg1tm1(cre)Skm/Foxg1+
Frs2tm1Fwan/Frs2tm1Fwan
Frs3tm1Jheb/Frs3tm1Jheb 		involves: 129 * Swiss Webster MGI:6116890


Genotype
MGI:3768916
cn1
Allelic
Composition		 Frs2tm1Fwan/Frs2tm1Fwan
Nkx2-5tm1(cre)Rjs/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frs2tm1Fwan mutation (0 available); any Frs2 mutation (63 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal interventricular septum morphology ( J:128712 )
• newborn mice do not have a fully developed wall separating the ventricules




Genotype
MGI:6116890
cn2
Allelic
Composition		 Foxg1tm1(cre)Skm/Foxg1+
Frs2tm1Fwan/Frs2tm1Fwan
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (30 available)
Frs2tm1Fwan mutation (0 available); any Frs2 mutation (63 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:242687 )
N
• differentiating field of cortical GABAergic interneurons at E13.5 according to Shh and Lhx6 labeling
abnormal cortical ventricular zone morphology ( J:242687 )
• reduced size of Dlx2-labeled region at E13.5
telencephalon hypoplasia ( J:242687 )
• reduction in size across A/P (-24%) and D/V (-16%) axes at E13.5
abnormal embryonic/fetal subventricular zone morphology ( J:242687 )
• reduced cell division at E13.5 according to mitotic marker p-HH3 immunoreactivity
abnormal lateral ganglionic eminence morphology ( J:242687 )
• reduction in subset of dopaminergic olfactory interneuron progenitors in dorsal LGE at E13.5 according to Pax6 labeling
abnormal medial ganglionic eminence morphology ( J:242687 )
• reduced size of Nkx2-1-labeled region in MGE and pre-optic area at E13.5
• size of Nkx2-1-labeled region in MGE and pre-optic area at E10.5
• reduced size of Lhx8-labeled differentiating domain at E13.5

craniofacial
frontonasal prominence hypoplasia ( J:242687 )
• at E10.5 and E13.5

vision/eye
microphthalmia ( J:242687 )
• at E13.5

cellular
cellular phenotype ( J:242687 )
N
• cell survival in telencephalon at E10.5 and E13.5




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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory