Phenotypes associated with this allele

• Allele Symbol: Frs2^tm1Fwan
• Allele Name: targeted mutation 1, Fen Wang
• Allele ID: MGI:3768912
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Frs2^tm1Fwan/Frs2^tm1Fwan Nkx2-5^tm1(cre)Rjs/?	involves: 129S7/SvEvBrd * C57BL/6	MGI:3768916
cn2	Foxg1^tm1(cre)Skm/Foxg1^+ Frs2^tm1Fwan/Frs2^tm1Fwan Frs3^tm1Jheb/Frs3^tm1Jheb	involves: 129 * Swiss Webster	MGI:6116890

Genotype
MGI:3768916

cn1

• Allelic Composition: Frs2^tm1Fwan/Frs2^tm1Fwan; Nkx2-5^tm1(cre)Rjs/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal interventricular septum morphology ( J:128712 )

• newborn mice do not have a fully developed wall separating the ventricules

Genotype
MGI:6116890

cn2

• Allelic Composition: Foxg1^tm1(cre)Skm/Foxg1⁺; Frs2^tm1Fwan/Frs2^tm1Fwan; Frs3^tm1Jheb/Frs3^tm1Jheb
• Genetic Background: involves: 129 * Swiss Webster

nervous system

nervous system phenotype ( J:242687 )

N • differentiating field of cortical GABAergic interneurons at E13.5 according to Shh and Lhx6 labeling

abnormal cortical ventricular zone morphology ( J:242687 )

• reduced size of Dlx2-labeled region at E13.5

telencephalon hypoplasia ( J:242687 )

• reduction in size across A/P (-24%) and D/V (-16%) axes at E13.5

abnormal embryonic/fetal subventricular zone morphology ( J:242687 )

• reduced cell division at E13.5 according to mitotic marker p-HH3 immunoreactivity

abnormal lateral ganglionic eminence morphology ( J:242687 )

• reduction in subset of dopaminergic olfactory interneuron progenitors in dorsal LGE at E13.5 according to Pax6 labeling

abnormal medial ganglionic eminence morphology ( J:242687 )

• reduced size of Nkx2-1-labeled region in MGE and pre-optic area at E13.5

• size of Nkx2-1-labeled region in MGE and pre-optic area at E10.5

• reduced size of Lhx8-labeled differentiating domain at E13.5

craniofacial

frontonasal prominence hypoplasia ( J:242687 )

• at E10.5 and E13.5

vision/eye

microphthalmia ( J:242687 )

• at E13.5

cellular

cellular phenotype ( J:242687 )

N • cell survival in telencephalon at E10.5 and E13.5