Analysis Tools|
Allele Symbol Allele Name Allele ID |
Map2k4tm1Ctr targeted mutation 1, Cathy Tournier MGI:3769117 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
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• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
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• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are slightly less able to hold onto a hanging wire than wild-type mice
• however, righting behavior is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons
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• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated neurons exhibit normal increases in neuron apoptosis following beta-amyloid 42 stimulation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by 21 days
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• radial migration of late-born neurons is delayed
• however, lamination of the cerebral cortex and radial glial cell formations are normal
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• at P20, the thickness of the corpus callosum is decreased due to defasciulation of cortical afferents
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• at P20, the thickness of the anterior commissure is decreased due to defasciulation of cortical afferents
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• unlike in wild-type mice, Purkinje cells that normally align beneath the inner granule layer are malpositioned
• at P20, the Purkinje cell layer is disorganized
• however, arborization of dendrites is normal
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• Purkinje cell size is reduced by 25% compared to wild-type
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• unlike in wild-type mice, the inner granule layer is loosely packed and Purkinje cells that normally align beneath it are malpositioned
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• at P14, mice exhibit impaired righting reflex when placed on their backs indicating decreased motor balance and coordination
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• in a hanging wire test, mice are 5 times less able to hold onto a hanging wire
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• between P13 and P15, mice exhibit an awkward gait
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• mice are noticeably smaller 7 days after birth and weight 40% of wild-type by day 20
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• although mice are born normal they stop growing a few days after birth
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• radial migration of late-born neurons is delayed
• however, lamination of the cerebral cortex and radial glial cell formations are normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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