Phenotypes associated with this allele

• Allele Symbol: Ncoa6^tm2Jxu
• Allele Name: targeted mutation 2, Jianming Xu
• Allele ID: MGI:3769253
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncoa6^tm2Jxu/Ncoa6^tm2Jxu	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3769257

Genotype
MGI:3769257

hm1

• Allelic Composition: Ncoa6^tm2Jxu/Ncoa6^tm2Jxu
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased liver weight ( J:129067 )

• when fed a high-cholesterol diet, liver weight is increased to a greater extent than in wild-type mice (3.88+/-0.11% compared to 3.74+/-0.12% in wild-type mice)

homeostasis/metabolism

abnormal lipid homeostasis ( J:129067 )

• the average number of lipid droplets per hepatocytes and the average size of droplets in the liver are reduced compared to in wild-type mice indicating an impairment in lipogenesis

• when fed a high-cholesterol diet the number and size of lipid droplets in the liver is increased to a greater extent than in wild-type mice

increased circulating cholesterol level ( J:129067 )

• when fed a high-cholesterol diet, plasma cholesterol levels are higher than in similarly treated wild-type mice

abnormal circulating triglyceride level ( J:129067 )

• treatment of mice with T0901317 does not result in as great an increase in triglyceride plasma levels as in similarly treated wild-type mice

abnormal bile salt homeostasis ( J:129067 )

• fecal bile acid content is lower than in wild-type mice when fed a high fat diet

liver/biliary system

abnormal liver morphology ( J:129067 )

• when fed a high-cholesterol diet the number and size of lipid droplets in the liver is increased to a greater extent than in wild-type mice

increased liver weight ( J:129067 )

• when fed a high-cholesterol diet, liver weight is increased to a greater extent than in wild-type mice (3.88+/-0.11% compared to 3.74+/-0.12% in wild-type mice)

abnormal hepatocyte morphology ( J:129067 )

• the average number of lipid droplets per hepatocytes and the average size of droplets in the liver are reduced compared to in wild-type mice indicating an impairment in lipogenesis

reproductive system

reproductive system phenotype ( J:129067 )

N • mice exhibit normal reproduction and mammary gland morphogenesis

digestive/alimentary system

abnormal feces composition ( J:129067 )

• fecal bile acid content is lower than in wild-type mice when fed a high fat diet