Phenotypes associated with this allele

• Allele Symbol: Tg(Lck-Jak3)1Ljb
• Allele Name: transgene insertion 1, Leslie J Berg
• Allele ID: MGI:3769344
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Jak3^tm1Ljb/Jak3^tm1Ljb Tg(Lck-Jak3)1Ljb/0	involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10	MGI:3769355

Genotype
MGI:3769355

cx1

• Allelic Composition: Jak3^tm1Ljb/Jak3^tm1Ljb; Tg(Lck-Jak3)1Ljb/0
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:128694 )

N • unlike null mice without the transgene, thymic cellularity, the ratio of CD4+ to CD8+ cells in the thymus, T cell maturation in the spleen, and the numbers of gamma delta T and NK cells are normal

decreased T cell proliferation ( J:128694 )

• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced

absent B cells ( J:128694 )

• absence of CD45R+ IgM+ cells in the bone marrow

absent lymph nodes ( J:128694 )

hematopoietic system

decreased T cell proliferation ( J:128694 )

• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced

absent B cells ( J:128694 )

• absence of CD45R+ IgM+ cells in the bone marrow

cellular

decreased T cell proliferation ( J:128694 )

• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced