All Phenotypes Hp<tm1Alev> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hp^tm1Alev/Hp^tm1Alev	involves: 129 * C57BL/6	MGI:3838400
cx2	Apoe^tm1Unc/Apoe^tm1Unc Hp^tm1Alev/Hp^tm1Alev	involves: 129	MGI:3790694

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cholesterol efflux ( J:129061 )

• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls

• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice

• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice

homeostasis/metabolism

decreased cholesterol efflux ( J:129061 )

• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls

• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice

• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice

renal/urinary system

increased kidney weight ( J:146516 )

• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)

abnormal renal glomerulus morphology ( J:146516 )

• induced diabetes leads to an increased total glomerular area greater than what is found in diabetic controls

abnormal proximal convoluted tubule morphology ( J:146516 )

• induced diabetes leads to an increased proximal tubule area greater than what is found in diabetic controls

decreased creatinine clearance ( J:146516 )

• induced diabetes leads to an increased creatinine clearance time that is around twice that compared to diabetic controls

• vitamin E treatment lowers this clearance time

growth/size/body

increased kidney weight ( J:146516 )

• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Hp^tm1Alev/Hp^tm1Alev
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Hp^tm1Alev mutation (0 available); any Hp mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:134942 )

• iron deposition in atherosclerotic lesions is almost two times greater than what is observed in mice that are homozygotes for just the Apoe^tm1Unc allele

• there is also increased amounts of oxidized lipids and proteins occurring in the plaques

immune system

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

cellular

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

hematopoietic system

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24