cellular
• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls
• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice
• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice
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homeostasis/metabolism
• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls
• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice
• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice
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renal/urinary system
• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)
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• induced diabetes leads to an increased total glomerular area greater than what is found in diabetic controls
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• induced diabetes leads to an increased proximal tubule area greater than what is found in diabetic controls
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• induced diabetes leads to an increased creatinine clearance time that is around twice that compared to diabetic controls
• vitamin E treatment lowers this clearance time
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growth/size/body
• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)
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