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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hptm1Alev
targeted mutation 1, Andrew P Levy
MGI:3769352
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hptm1Alev/Hptm1Alev involves: 129 * C57BL/6 MGI:3838400
cx2
Apoetm1Unc/Apoetm1Unc
Hptm1Alev/Hptm1Alev
involves: 129 MGI:3790694


Genotype
MGI:3838400
hm1
Allelic
Composition
Hptm1Alev/Hptm1Alev
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hptm1Alev mutation (0 available); any Hp mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls
• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice
• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice

homeostasis/metabolism
• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls
• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice
• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice

renal/urinary system
• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)
• induced diabetes leads to an increased total glomerular area greater than what is found in diabetic controls
• induced diabetes leads to an increased proximal tubule area greater than what is found in diabetic controls
• induced diabetes leads to an increased creatinine clearance time that is around twice that compared to diabetic controls
• vitamin E treatment lowers this clearance time

growth/size/body
• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)




Genotype
MGI:3790694
cx2
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Hptm1Alev/Hptm1Alev
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Hptm1Alev mutation (0 available); any Hp mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• iron deposition in atherosclerotic lesions is almost two times greater than what is observed in mice that are homozygotes for just the Apoetm1Unc allele
• there is also increased amounts of oxidized lipids and proteins occurring in the plaques

immune system
• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoetm1Unc allele

cellular
• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoetm1Unc allele

hematopoietic system
• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoetm1Unc allele





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory