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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad9tm1Jfm
targeted mutation 1, James F Martin
MGI:3769363
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad9tm1Jfm/Smad9tm1Jfm involves: 129S4/SvJaeSor * 129S6/SvEvTac MGI:3850123
cn2
 		Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
Smad9tm1Jfm/Smad9tm1Jfm 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 MGI:3769375


Genotype
MGI:3850123
hm1
Allelic
Composition		 Smad9tm1Jfm/Smad9tm1Jfm
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad9tm1Jfm mutation (0 available); any Smad9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:150213 )
N
• despite expression of the endogenous gene during development no gross developmental abnormalities are seen




Genotype
MGI:3769375
cn2
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
Smad9tm1Jfm/Smad9tm1Jfm
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Smad1tm2Rob mutation (1 available); any Smad1 mutation (32 available)
Smad5tm1Huy mutation (0 available); any Smad5 mutation (23 available)
Smad5tm1Zuk mutation (1 available); any Smad5 mutation (23 available)
Smad9tm1Jfm mutation (0 available); any Smad9 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased ovary tumor incidence ( J:128934 )
• after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors
increased ovarian carcinoma incidence ( J:128934 )
• over 70% of female mice have metastic ovarian cancer by 1 year of age

mortality/aging
early reproductive senescence ( J:128934 )
• female mice become infertile after 3 to 4 months of breeding

reproductive system
increased ovary tumor incidence ( J:128934 )
• after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors
increased ovarian carcinoma incidence ( J:128934 )
• over 70% of female mice have metastic ovarian cancer by 1 year of age
early reproductive senescence ( J:128934 )
• female mice become infertile after 3 to 4 months of breeding

neoplasm
increased ovary tumor incidence ( J:128934 )
• after 3 months of age, 100% of female mice have unilateral or bilateral ovarian tumors
increased ovarian carcinoma incidence ( J:128934 )
• over 70% of female mice have metastic ovarian cancer by 1 year of age

cardiovascular system
hemoperitoneum ( J:128934 )
• found in 50% of female mice over 9 months in age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory