All Phenotypes Kat8<tm2Thl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kat8^tm2Thl
targeted mutation 2, Thomas Ludwig
MGI:3769376

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat8^tm2Thl/Kat8^tm2Thl	involves: 129S1/Sv	MGI:3769384
cx2	Atm^tm1Led/Atm⁺ Kat8^tm2Thl/Kat8⁺	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3769385
cx3	Atm^tm1Led/Atm^tm1Led Kat8^tm2Thl/Kat8⁺	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3769386
cx4	Kat8^tm2Thl/Kat8⁺ Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:3769387

Allelic Composition	Kat8^tm2Thl/Kat8^tm2Thl
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat8^tm2Thl mutation (0 available); any Kat8 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:128936 )

• mice die prior to the onset of gastrulation and are all dead by E7.5

embryo

abnormal embryo development ( J:128936 )

• by E7.5, deciduas contain only clusters of cells within a small sac or some giant cells only

Allelic Composition	Atm^tm1Led/Atm⁺ Kat8^tm2Thl/Kat8⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Led mutation (0 available); any Atm mutation (170 available)
Kat8^tm2Thl mutation (0 available); any Kat8 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:128936 )

• only 76% of mice survive the first year

Allelic Composition	Atm^tm1Led/Atm^tm1Led Kat8^tm2Thl/Kat8⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:128936 )

• mice die earlier than Atm^tm1Led homozygotes

growth/size/body

decreased body weight ( J:128936 )

• mice exhibit a modest reduction in weight compared to Atm^tm1Led homozygotes

Allelic Composition	Kat8^tm2Thl/Kat8⁺ Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat8^tm2Thl mutation (0 available); any Kat8 mutation (38 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:128936 )

• mice die earlier than Trp53^tm1Brdhomozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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