Phenotypes associated with this allele

• Allele Symbol: Gjb5^tm1Kwi
• Allele Name: targeted mutation 1, Klaus Willecke
• Allele ID: MGI:3769388
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gjb5^tm1Kwi/Gjb5^tm1Kwi	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3769392

Genotype
MGI:3769392

hm1

• Allelic Composition: Gjb5^tm1Kwi/Gjb5^tm1Kwi
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:128922 )

• 30% of mice die between E11.5 and E14.5

embryo

abnormal spongiotrophoblast layer morphology ( J:128922 )

• at E10.5, the thickness of the spongiotrophoblast layer is increased (158.4+/-48.5 um compared to 75.5+/-22.2 um in wild-type mice) and cells within this layer exhibit a 2-fold increase in diameter with increased nuclear volume

• unlike in wild-type mice, spongiotrophoblast cells form a cell around the few and small lacunae remaining from the maternal blood supply

• at E13.5, the spongiotrophoblast layer is more compact with reduced lacunae for maternal blood flow compared to in wild-type mice

decreased placenta weight ( J:128922 )

• starting at E12.5 untilE18.5 placenta weight is 85% of wild-type

abnormal placenta development ( J:128922 )

• at E10.5, differentiation of the three trophoblast layers is impaired

growth/size/body

decreased fetal weight ( J:128922 )

• at E17.5, fetal weight is 93% of wild-type and by E18.5 it is 88% of wild-type