Analysis Tools
mortality/aging
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• die around E10.5
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embryo
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• arteries are smaller and less well defined compared to wild-type mice
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• however, placental development appears normal
• absence of a branching vascular network at E9.5 and E10.5
• at E9.5 dilated blood vessels are present
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• reduced in size by E9.5
• about half the size of wild-type and heterozygous littermates at E10.5
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• at E9.5 and E10.5 the surface of the yolk sac appears pitted and pale
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• endothelial cells are present but fail to organize into a vascular network
• smooth muscle cells accumulate in a spotted punctate pattern
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cardiovascular system
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• fewer small capillaries in the head region
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• smaller and less well defined
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• at E9.5
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• arteries are smaller and less well defined compared to wild-type mice
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• reduction in the number of branch points in the perineural vascular plexus compared to wild-type controls at E9.5
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• reduction in the number of branch points in the perineural vascular plexus compared to wild-type controls at E9.5
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• absence of a branching vascular network at E9.5 and E10.5
• at E9.5 dilated blood vessels are present
• however, placental development appears normal
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• smaller and underdeveloped at E9.5
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• at E9.5 the left valve is smaller and underdeveloped
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growth/size/body
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• reduced in size by E9.5
• about half the size of wild-type and heterozygous littermates at E10.5
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cellular
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• reduced proliferation of MEFs
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hematopoietic system
| N |
• despite anemic appearance, no significant difference in erythroid, myeloid or mixed colony formation is seen in colony forming assays using yolk sac derived cells from homozygous or wild-type embryos
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craniofacial
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• arteries are smaller and less well defined compared to wild-type mice
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integument
