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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ets2tm3Rgo
targeted mutation 3, Robert G Oshima
MGI:3769393
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ets2tm3Rgo/Ets2tm3Rgo involves: 129S1/Sv * 129X1/SvJ MGI:3769395
cn2
 		Ets2tm3Rgo/Ets2tm3Rgo involves: 129S1/Sv * 129X1/SvJ MGI:3769398
cn3
 		Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3769399
cn4
 		Ets2tm2Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3769401
cn5
 		Ets2tm3Rgo/Ets2tm3.1Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/? 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3615252
cn6
 		Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/? 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3615263
cn7
 		Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/? 		involves: 129S4/SvJaeSor * FVB/N MGI:3615264
cn8
 		Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/? 		involves: 129S4/SvJaeSor * FVB/N MGI:3615265


Genotype
MGI:3769395
hm1
Allelic
Composition		 Ets2tm3Rgo/Ets2tm3Rgo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:128952 )
• mice have normal development and lifespan




Genotype
MGI:3769398
cn2
Allelic
Composition		 Ets2tm3Rgo/Ets2tm3Rgo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal trophoblast layer morphology ( J:128952 )
• when transfected with an adenovirus Cre, trophoblast stem cells exhibit reduced growth and self-renewal
• however, trophoblast cells transfected with an adenovirus Cre differentiate normally




Genotype
MGI:3769399
cn3
Allelic
Composition		 Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal visceral yolk sac morphology ( J:128952 )
• at E7.5, yolk sacs are cone-shaped

growth/size/body
decreased embryo size ( J:128952 )
• at E7.5




Genotype
MGI:3769401
cn4
Allelic
Composition		 Ets2tm2Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (39 available)
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:128952 )
• mice die around mid-gestation




Genotype
MGI:3615252
cn5
Allelic
Composition		 Ets2tm3Rgo/Ets2tm3.1Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:102368 )
• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group
• once tumors appeared, the rate of tumor growth was not detectably altered

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:102368 )
• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group
• once tumors appeared, the rate of tumor growth was not detectably altered
mammary gland hyperplasia ( J:102368 )
• the epithelial hyperplasia of mutant mice filled less of the mammary fat pad than control

integument
increased mammary gland tumor incidence ( J:102368 )
• delayed onset of mammary tumors with a median onset of 174 days, a significant delay of 37 days from control group
• once tumors appeared, the rate of tumor growth was not detectably altered
mammary gland hyperplasia ( J:102368 )
• the epithelial hyperplasia of mutant mice filled less of the mammary fat pad than control




Genotype
MGI:3615263
cn6
Allelic
Composition		 Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:3615264
cn7
Allelic
Composition		 Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
Genetic
Background		 involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-cre)7Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:3615265
cn8
Allelic
Composition		 Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
Genetic
Background		 involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (39 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-cre)7Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory