Analysis Tools|
Allele Symbol Allele Name Allele ID |
Errfi1tm1Jwj targeted mutation 1, Jae-Wook Jeong MGI:3769404 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• survival time of double mutants is shorter than either single mutant, with mice dying by 16 weeks of age
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• development of endometrial cancer is accelerated compared to either single mutant
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• decrease in the number of apoptotic cells in the endothelium epithelium compared to single Pten mutants
• proliferation is increased in the endothelium epithelium
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• mutants exhibit endometrial hyperplasia at 2 weeks of age and develop endometrial adenocarcinoma at 4 weeks of age
• however, myometrial hyperplasia is not observed in the uteri of mutants
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• increase in uterine weight at 2 weeks of age, with weight at 4 weeks greater than in single Pten mutants
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• mutants exhibit distant metastases into the ovary, diaphragmatic skeletal muscle, lymph node, colon and pancreas
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• development of endometrial cancer is accelerated compared to either single mutant
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| endometrial cancer | DOID:1380 |
OMIM:608089 |
J:162027 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in the ratio of gland to stroma compared to in Errfi1tm1Jwj homozygotes
• however, the myometrium is not enlarged
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• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes
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• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle
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• mice develop endometrial hyperplasia
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• at 5 months, uterine wet weight is increased compared to in Errfi1tm1Jwj homozygotes
• after 3 months, ovectamized mice treated with E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1tm1Jwj homozygotes
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• despite normal oocyte numbers and uterine environment, female mice are infertile
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• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle
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• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| endometrial cancer | DOID:1380 |
OMIM:608089 |
J:150007 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• following tamoxifen treatment, mice display normal alveolar spaces and normal lung structure with no detectable mucosal cells
• expression of key lung molecular markers remains normal in adult lungs
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• following tamoxifen treatment, mice display uterine hyperplasia
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• following tamoxifen treatment, mice display dermal papillomas
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• following tamoxifen treatment, mice display dermal papillomas
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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