Phenotypes associated with this allele

• Allele Symbol: Trdn^tm1.1Cfp
• Allele Name: targeted mutation 1.1, Claudio F Perez
• Allele ID: MGI:3769415
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trdn^tm1.1Cfp/Trdn^tm1.1Cfp	involves: 129X1/SvJ * FVB/N	MGI:3769416

Genotype
MGI:3769416

hm1

• Allelic Composition: Trdn^tm1.1Cfp/Trdn^tm1.1Cfp
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle fiber triad morphology ( J:128951 )

• the triads lose their predominantly transverse orientation and acquire an oblique or longitudinal orientation

• more than a third of the skeletal muscle area counted contained a higher percentage of longitudinal triads (20% and 50%, respectively, in the extensor digitorum longus and sternomastoid muscles, compared to 5-15% in wild-type mice)

• however, excitation contraction coupling occurs normally