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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cadm1tm1Momo
targeted mutation 1, Takashi Momoi
MGI:3769418
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cadm1tm1Momo/Cadm1tm1Momo involves: 129S/SvEv MGI:3769420
hm2
 		Cadm1tm1Momo/Cadm1tm1Momo involves: 129S/SvEv * C57BL/6J MGI:3769419


Genotype
MGI:3769420
hm1
Allelic
Composition		 Cadm1tm1Momo/Cadm1tm1Momo
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadm1tm1Momo mutation (2 available); any Cadm1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased elongated spermatid number ( J:128950 )
• elongated spermatids are not present

nervous system
nervous system phenotype ( J:199632 )
N
• no neurological abnormalities are detected

cellular
decreased elongated spermatid number ( J:128950 )
• elongated spermatids are not present




Genotype
MGI:3769419
hm2
Allelic
Composition		 Cadm1tm1Momo/Cadm1tm1Momo
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadm1tm1Momo mutation (2 available); any Cadm1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:129496 )
• elongated spermatids have abnormal head shapes, abnormally arranged mitochondria and erroneously attached flagella
• symplasts formed of undivided elongating spermatids are frequently formed
decreased male germ cell number ( J:129496 )
• spermatozoa are almost completely lost from the seminiferous tubules
• few elongated spermatids are present
abnormal testis weight ( J:129496 )
• testes weight is 15% less than in wild-type mice
arrest of spermiogenesis ( J:129496 )
• elongating spermatids fail to progress into further maturation steps and are not translocated to the adluminal surface
• round spermatids develop normally but condensation of elongated spermatids is incomplete

endocrine/exocrine glands
abnormal testis weight ( J:129496 )
• testes weight is 15% less than in wild-type mice

cellular
abnormal spermatid morphology ( J:129496 )
• elongated spermatids have abnormal head shapes, abnormally arranged mitochondria and erroneously attached flagella
• symplasts formed of undivided elongating spermatids are frequently formed
decreased male germ cell number ( J:129496 )
• spermatozoa are almost completely lost from the seminiferous tubules
• few elongated spermatids are present




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory