About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sulf2Gt(OST311938)Lex
gene trap OST311938, Lexicon Genetics
MGI:3769472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex involves: 129S5/SvEvBrd * C57BL/6N MGI:3769476
cx2
Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex
Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
involves: 129S5/SvEvBrd * C57BL/6N MGI:3769477


Genotype
MGI:3769476
hm1
Allelic
Composition
Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2Gt(OST311938)Lex mutation (1 available); any Sulf2 mutation (177 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 16 to 18 months of age, female mice weigh 38% less (24.6+/-1.6 g compared to 39.6+/-3.7 g for wild-type mice)
• at 14 to 15 weeks of age male mice exhibit a 20% reduction in body weight (23.3+/-0.8 g compared to 29.3+/-0.6 g for wild-type mice)
• all organs except the kidney exhibit proportional decrease in weight

renal/urinary system




Genotype
MGI:3769477
cx2
Allelic
Composition
Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex
Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf1Gt(OST352220)Lex mutation (1 available); any Sulf1 mutation (112 available)
Sulf2Gt(OST311938)Lex mutation (1 available); any Sulf2 mutation (177 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex embryos display several development defects

mortality/aging
• long term survival is 18%
• some mice that survive weaning die within 10 days of weaning
• long term survival is 18%
• fewer than expected mice survive postnatal day 1 to 2 and die with empty stomachs
• few mice that survive past the first week of life survive to weaning

growth/size/body
• mice weigh 19% less than wild-type mice
• at week 14 to 15, male mice weigh 26% less than wild-type mice and female mice weigh 29% less than wild-type mice
• mice measure 12% less in length than wild-type mice

skeleton
• the posterior basisphenoid bone fails to fuse and is aberrantly fused to the basioccipital bone
• at E18.5, 12 of 14 mice exhibit asymmetric and/or fused sternebrae compared to only 1 of 19 wild-type mice
• at E18.5, 12 of 14 mice exhibit asymmetric and/or fused sternebrae compared to only 1 of 19 wild-type mice
• bone volume is decreased in the humerus (by 21.4%), femur (by 15.7%), frontal (by 6.8%), interparietal (by 15.3%, supraoccipital (by 22.6%), basioccipital (by 15.5%, and basiphenoid (by 13.6%)
• the distal chondrocyte population is smaller than in wild-type mice

renal/urinary system
• kidney volume is reduced 45% compared to in heterogygous mice

craniofacial
• the posterior basisphenoid bone fails to fuse and is aberrantly fused to the basioccipital bone





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory