About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sphk1tm1Npa
targeted mutation 1, Novartis Pharma AG
MGI:3769485
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sphk1tm1Npa/Sphk1tm1Npa BALB/c-Sphk1tm1Npa MGI:3769495


Genotype
MGI:3769495
hm1
Allelic
Composition		 Sphk1tm1Npa/Sphk1tm1Npa
Genetic
Background		 BALB/c-Sphk1tm1Npa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sphk1tm1Npa mutation (0 available); any Sphk1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:129314 )
• when treated with 1mg/kg FTY720, mice exhibit a 75% reduction in peripheral lymphocytes compared to wild-type mice

hematopoietic system
increased B cell number ( J:129314 )
• when treated with 1mg/kg FTY720, mice exhibit a 75% reduction in peripheral lymphocytes compared to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory