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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sphk2tm1Npa
targeted mutation 1, Novartis Pharma AG
MGI:3769486
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sphk2tm1Npa/Sphk2tm1Npa BALB/c-Sphk2tm1Npa MGI:3769496


Genotype
MGI:3769496
hm1
Allelic
Composition		 Sphk2tm1Npa/Sphk2tm1Npa
Genetic
Background		 BALB/c-Sphk2tm1Npa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sphk2tm1Npa mutation (0 available); any Sphk2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal B cell migration ( J:129314 )
• unlike in wild-type mice, lymphocyte migration in FTY720-treated mice continue to migrate in response to S1P (shingosine-1-phosphate)

immune system
abnormal B cell migration ( J:129314 )
• unlike in wild-type mice, lymphocyte migration in FTY720-treated mice continue to migrate in response to S1P (shingosine-1-phosphate)
increased B cell number ( J:129314 )
• when treated with 1mg/kg FTY720, mice fail to exhibit reduction in peripheral lymphocytes compared to wild-type mice

hematopoietic system
abnormal B cell migration ( J:129314 )
• unlike in wild-type mice, lymphocyte migration in FTY720-treated mice continue to migrate in response to S1P (shingosine-1-phosphate)
increased B cell number ( J:129314 )
• when treated with 1mg/kg FTY720, mice fail to exhibit reduction in peripheral lymphocytes compared to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory