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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgef1tm1Djle
targeted mutation 1, David J Lerner
MGI:3769502
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgef1tm1Djle/Arhgef1tm1Djle involves: 129S4/SvJae MGI:5140846
hm2
 		Arhgef1tm1Djle/Arhgef1tm1Djle involves: 129S4/SvJae * C57BL/6 MGI:3769503


Genotype
MGI:5140846
hm1
Allelic
Composition		 Arhgef1tm1Djle/Arhgef1tm1Djle
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef1tm1Djle mutation (0 available); any Arhgef1 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased germinal center B cell number ( J:174313 )
• in germinal centers when bone marrow cells are used to reconstitute wild-type mice

hematopoietic system
increased germinal center B cell number ( J:174313 )
• in germinal centers when bone marrow cells are used to reconstitute wild-type mice




Genotype
MGI:3769503
hm2
Allelic
Composition		 Arhgef1tm1Djle/Arhgef1tm1Djle
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef1tm1Djle mutation (0 available); any Arhgef1 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased leukocyte cell number ( J:129331 )
• the number of neutrophils and lymphocytes is increased 2-fold compared to in wild-type mice
abnormal neutrophil physiology ( J:129331 )
• when stimulated with formyl-peptide, neutrophils form and retract pseudopodia at inappropriate locations around the entire perimeter of the cell, migrate slower than wild-type neutrophils, and exhibit decreased adhesion

hematopoietic system
extramedullary hematopoiesis ( J:129331 )
• in the red pulp of the spleen
increased leukocyte cell number ( J:129331 )
• the number of neutrophils and lymphocytes is increased 2-fold compared to in wild-type mice
abnormal neutrophil physiology ( J:129331 )
• when stimulated with formyl-peptide, neutrophils form and retract pseudopodia at inappropriate locations around the entire perimeter of the cell, migrate slower than wild-type neutrophils, and exhibit decreased adhesion

growth/size/body
enlarged spleen ( J:129331 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory