Phenotypes associated with this allele

• Allele Symbol: Tbx3^tm1Jcib
• Allele Name: targeted mutation 1, Juan Carlos Belmonte
• Allele ID: MGI:3769504
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx3^tm1Jcib/Tbx3^tm1Jcib	involves: 129S4/SvJae * C57BL/6	MGI:3769511

Genotype
MGI:3769511

hm1

• Allelic Composition: Tbx3^tm1Jcib/Tbx3^tm1Jcib
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vitelline vasculature morphology ( J:129349 )

• mice exhibit poorly developed yolk sac vasculature

abnormal fetal atrioventricular canal morphology ( J:129349 )

• the constriction at the atrioventricular canal (AVC) is expanded

• the number of proliferating cells in the AVC is increased compared to in wild-type mice

abnormal heart looping ( J:129349 )

• at E10.5, 33% of mice exhibit improper heart looping

delayed heart looping ( J:129349 )

• at E9.5, 4 of 40 mice exhibit delayed heart looping

failure of heart looping ( J:129349 )

• at E11.5, 43% of mice recovered exhibit swollen pericardiam cavities and an unlooped heart

pericardial edema ( J:129349 )

• at E10.5, 33% of mice exhibit swelling in the pericardial cavity

• at E11.5, 43% of mice exhibit swollen pericardiam cavities and an unlooped heart

embryo

abnormal vitelline vasculature morphology ( J:129349 )

• mice exhibit poorly developed yolk sac vasculature

growth/size/body

decreased body size ( J:129349 )

limbs/digits/tail

short hindlimb ( J:129349 )

• mice exhibit truncated hindlimbs

homeostasis/metabolism

pericardial edema ( J:129349 )

• at E10.5, 33% of mice exhibit swelling in the pericardial cavity

• at E11.5, 43% of mice exhibit swollen pericardiam cavities and an unlooped heart