Analysis Tools
reproductive system
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit necrosis in decidua cells
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• when females carrying Tg(AGT)2-5Afu are mated with males carrying the Tg(REN)8-12Afu transgene, the females develop hypertension during pregnancy, with blood pressure beginning to increase at 14 days of gestation and continuing to rise until the day before deliver and returns to normal levels by 3 days after delivery
(J:130455)
(J:194606)
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, delivery is delayed in all of the surviving hypertensive pregnant females
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mortality/aging
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, only 38% of pregnant females survive throughout pregnancy
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cardiovascular system
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit myocardial concentric hypertrophy
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit increased heart weight and heart weight to body weight ratio at E19, whereas a reduction in heart weight is seen in both lactating and non-lactating females at 4 weeks post-partum
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females show cardiac fibrosis at E19 and similar levels of fibrosis are seen in non-lactating and lactating females at 4 weeks post-partum
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hemorrhage
(
J:130455
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, 23% of the pregnant females exhibit intrathoracic or intra-abdominal hemorrhage
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, lactating females at 4 weeks post-partum exhibit a decrease in fractional shortening indicating decreased cardiac contractility compared to non-lactating females
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hypertension
(
J:130455
)
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• when females carrying Tg(AGT)2-5Afu are mated with males carrying the Tg(REN)8-12Afu transgene, the females develop hypertension during pregnancy, with blood pressure beginning to increase at 14 days of gestation and continuing to rise until the day before deliver and returns to normal levels by 3 days after delivery; this increase is due to expression of paternal human renin in the placenta and secretion into the maternal circulation
• females mated with wild-type males do not develop hypertension during pregnancy and nonpregnant females exhibit normal blood pressure
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit an increase in systolic blood pressure at E19 of pregnancy that goes back to normal in both lactating and non-lactating females in the postpartum period
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit elevated macrophage infiltration into cardiac tissue at E19 which is improved in both lactating and non-lactating females at 4 weeks post-partum
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behavior/neurological
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, 15% of the hypertensive pregnant females exhibit generalized convulsions late in pregnancy
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embryo
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit congestion in chorion cells
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit edematous enlargement of the placenta
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit necrosis in decidua cells
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit necrosis in spongiotrophoblasts
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homeostasis/metabolism
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit an increase in urinary protein excretion
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immune system
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit elevated macrophage infiltration into cardiac tissue at E19 which is improved in both lactating and non-lactating females at 4 weeks post-partum
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muscle
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit myocardial concentric hypertrophy
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, lactating females at 4 weeks post-partum exhibit a decrease in fractional shortening indicating decreased cardiac contractility compared to non-lactating females
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nervous system
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, 15% of the hypertensive pregnant females exhibit generalized convulsions late in pregnancy
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renal/urinary system
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit an increase in urinary protein excretion
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit enlarged glomeruli
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growth/size/body
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit myocardial concentric hypertrophy
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the pregnant females exhibit increased heart weight and heart weight to body weight ratio at E19, whereas a reduction in heart weight is seen in both lactating and non-lactating females at 4 weeks post-partum
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cellular
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• when females are mated with males carrying the Tg(REN)8-12Afu transgene, the hypertensive pregnant females have the ability to breastfeed foster pups, however foster wild-type pups are smaller than pups nursed by wild-type dams
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