mortality/aging
• fetal death rate in litters of transgenic dams is 12%, compared to no lethality in litters from wild-type dams
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embryo
• at E11.5, embryonic growth restriction is observed in transgenic dams
• at E14.5 and 17.5 fetal growth is similar in transgenic and wild-type dams
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• at E11.5, fetuses exhibit a ~10% reduction in weight compared to wild-type fetuses; difference is less at E14.5 and by E17.5, mutants and wild-type have very similar growth characteristics
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• decidual component of placentas in wild-type dams is greater than that of transgenic dams
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• junctional zone is larger in placentae from wild-type females compared to transgenic mice
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• ratio of spongiotrophoblasts to glycogen cells is higher in transgenic females
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• labyrinthine zone is grossly enlarged in transgenic females, occupying 80% of cross-sectional area of placenta in transgenic females, compared to ~50% of area in wild-type females
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• transgenic dams have higher mean placental weights throughout gestation
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growth/size/body
• at E11.5, embryonic growth restriction is observed in transgenic dams
• at E14.5 and 17.5 fetal growth is similar in transgenic and wild-type dams
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• at E11.5, fetuses exhibit a ~10% reduction in weight compared to wild-type fetuses; difference is less at E14.5 and by E17.5, mutants and wild-type have very similar growth characteristics
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reproductive system
• decidual component of placentas in wild-type dams is greater than that of transgenic dams
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