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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bdnftm1Limm
targeted mutation 1, Lisa M Monteggia
MGI:3770141
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Bdnftm1Limm/Bdnftm1Limm
Tg(Camk2a-cre)T50Stl/0
involves: BALB/c * C57BL/6 MGI:3770148
cn2
Bdnftm1Limm/Bdnftm1Limm
Tg(GFAP-cre)25Mes/0
involves: FVB/N MGI:3770149


Genotype
MGI:3770148
cn1
Allelic
Composition
Bdnftm1Limm/Bdnftm1Limm
Tg(Camk2a-cre)T50Stl/0
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Limm mutation (0 available); any Bdnf mutation (42 available)
Tg(Camk2a-cre)T50Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• female, but not male, mice exhibit reduced preference for a natural reward in sucrose preference tests compared to wild-type mice
• female, but not male, mice exhibit more immobility when placed in swim test than wild-type mice
• unlike wild-type mice, female and male mice do not exhibit any decrease in immobility following administration of desipramine
• male, but not female, mice exhibit increased locomotor activity compared to same sex wild-type mice
• however, activity levels are normal after 4 days of habituation




Genotype
MGI:3770149
cn2
Allelic
Composition
Bdnftm1Limm/Bdnftm1Limm
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Limm mutation (0 available); any Bdnf mutation (42 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• female, but not male, mice exhibit more immobility when placed in swim test than wild-type female mice
• male, but not female, mice exhibit increased locomotor activity compared to same sex wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory