Phenotypes associated with this allele

• Allele Symbol: Pbx1^tm1.1Febe
• Allele Name: targeted mutation 1.1, Felix Beuschlein
• Allele ID: MGI:3770151
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pbx1^tm1.1Febe/Pbx1^tm1.1Febe	involves: C57BL/6	MGI:3770152
ht2	Pbx1^tm1.1Febe/Pbx1^+	involves: C57BL/6	MGI:3770153

Genotype
MGI:3770152

hm1

• Allelic Composition: Pbx1^tm1.1Febe/Pbx1^tm1.1Febe
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hunched posture ( J:129552 )

• at E14.5

cardiovascular system

abnormal vasculogenesis ( J:129552 )

• at E14.5, mice exhibit diminished vascularization

growth/size/body

abnormal embryonic growth/weight/body size ( J:129552 )

• at E14.5, mice possess slender thorax and abdomen

homeostasis/metabolism

skin edema ( J:129552 )

• at E14.5

limbs/digits/tail

abnormal limb morphology ( J:129552 )

• at E14.5, mice exhibit abnormally oriented fore- and hindlimbs

integument

skin edema ( J:129552 )

• at E14.5

pallor ( J:129552 )

• at E14.5

Genotype
MGI:3770153

ht2

• Allelic Composition: Pbx1^tm1.1Febe/Pbx1⁺
• Genetic Background: involves: C57BL/6

endocrine/exocrine glands

decreased adrenal gland zona fasciculata size ( J:129552 )

• mice exhibit a reduction in the number of cells in the zona fasciculate (63.3+/-3.3% compared to 89.3+/-8.3% in wild-type mice)

small adrenal glands ( J:129552 )

• 4.4+/-0.4 mg compared to 7.5+/-0.3 mg in wild-type mice

• adrenal glands are smaller due to decreased proliferation

• adrenal glands exhibit decreased compensatory adrenal growth compared to in wild-type mice when one adrenal is removed

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:129552 )

• mice exhibit a blunted steroid response after stimulation with ACTH

• however, corticosterone response following restrained stress experiments is normal