Phenotypes associated with this allele

• Allele Symbol: Adipor2^tm2Dgen
• Allele Name: targeted mutation 2, Deltagen
• Allele ID: MGI:3770154
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adipor2^tm2Dgen/Adipor2^tm2Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3770157

Genotype
MGI:3770157

hm1

• Allelic Composition: Adipor2^tm2Dgen/Adipor2^tm2Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:129554 )

• mice gain less weight in response to a high fat diet than do wild-type mice

decreased circulating cholesterol level ( J:129554 )

• while cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice

decreased circulating HDL cholesterol level ( J:129554 )

• while HDL cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice

decreased circulating LDL cholesterol level ( J:129554 )

• while LDL/lgHDL cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice

decreased circulating VLDL cholesterol level ( J:129554 )

• while VLDL cholesterol levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice

decreased circulating triglyceride level ( J:129554 )

• while triglyceride levels of mice on a high fat diet increase they remain lower than in similarly treated wild-type mice

abnormal glucose homeostasis ( J:129554 )

• when fed a high fat diet mice exhibit less diet-induced insulin resistance compared to wild-type mice

increased circulating glucose level ( J:129554 )

• 186 mg/dl compared to 143 mg/dl in wild-type mice on a high fat diet

decreased circulating insulin level ( J:129554 )

• while insulin levels increase in response to a high fat diet the increase is less than in wild-type mice

increased circulating adiponectin level ( J:129554 )

• when fed a high fat diet, adiponectin plasma levels rise early during the diet and continue to climb as they decrease in wild-type mice

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:129554 )

• unlike in wild-type mice fed a high fat diet, the number and size of pancreatic beta cells is not increased

growth/size/body

decreased susceptibility to diet-induced obesity ( J:129554 )

• mice gain less weight in response to a high fat diet than do wild-type mice