Phenotypes associated with this allele

• Allele Symbol: Casp14^tm1Wdec
• Allele Name: targeted mutation 1, Wim Declercq
• Allele ID: MGI:3770173
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp14^tm1Wdec/Casp14^tm1Wdec	Not Specified	MGI:3770174

Genotype
MGI:3770174

hm1

• Allelic Composition: Casp14^tm1Wdec/Casp14^tm1Wdec
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

dehydration ( J:129490 )

• transepidermal water loss is 20% higher than in wild-type mice and the hydration level of the stratum corneum is 20% lower than in wild-type mice

impaired skin barrier function ( J:129490 )

integument

integument phenotype ( J:129490 )

N • hair and skin development are normal

impaired skin barrier function ( J:129490 )

abnormal epidermis stratum corneum morphology ( J:129490 , J:130935 )

• the hydration level of the stratum corneum is 20% lower than in wild-type mice (J:129490)

• 3 hours after tape stripping, cornified envelops fail to form or are highly attenuated in transitional cells unlike in wild-type mice (J:130935)

shiny skin ( J:129490 )

• mice exhibit shinier and more lechenified skin than wild-type mice

increased sensitivity to skin irradiation ( J:129490 )

• mice sustain more damage and produce more apoptotic skin cells than wild-type mice when irradiated with UVB