Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Chrm3*)1Jwe
• Allele Name: transgene insertion 1, Jurgen Wess
• Allele ID: MGI:3770248
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-Chrm3*)1Jwe/0	involves: C57BL/6	MGI:3770249

Genotype
MGI:3770249

tg1

• Allelic Composition: Tg(Ins2-Chrm3*)1Jwe/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:158245 )

N • mice exhibit normal glucose metabolism whether fed a standard or high fat diet

abnormal glucose homeostasis ( J:129643 )

• mice are resistant to diet-induced hyperglycemia and glucose intolerance unlike wild-type mice

increased insulin secretion ( J:129643 )

hypoglycemia ( J:129643 )

• blood glucose is reduced 25% compared to in wild-type mice

increased circulating insulin level ( J:129643 )

improved glucose tolerance ( J:129643 )

• following administration of glucose, plasma glucose levels are decreased and insulin levels are increased 2- to 3-fold compared to in wild-type mice

endocrine/exocrine glands

increased insulin secretion ( J:129643 )

growth/size/body

growth/size/body region phenotype ( J:158245 )

N • mice exhibit normal weight and growth whether fed a standard or high fat diet