Analysis Tools
growth/size/body
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• at weaning, mice homozygous for this mutation are visibly larger than control littermates
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homeostasis/metabolism
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• homozygous mutant mice exhibit greatly elevated blood glucose levels (600-850 mg/ml)
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• homozygous mutants exhibit very low plasma insulin levels (1-4 ng/ml)
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• livers of mutant mice contain high levels of glycogen (i.e., are strongly PAS-positive)
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endocrine/exocrine glands
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• mutant adrenals exhibit hyperplasia of the zona reticularis
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• pancreatic beta cells of homozygous mutant mice are small and atrophic
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• mutant pancreatic beta cells are degranulated
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• diabetic female mice exhibit diminished numbers of developing and ovulated follicles (based on numbers of corpora lutea) vs. control littermates
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• diabetic female mice exhibit diminished numbers of developing and ovulated follicles (based on numbers of corpora lutea) vs. control littermates
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liver/biliary system
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• livers of mutant mice contain high levels of glycogen (i.e., are strongly PAS-positive)
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• homozygous mutant mice exhibit hepatic steatotis
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reproductive system
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• mutant female mice have fewer primary oocytes and follicles than do control littermates
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• diabetic female mice exhibit diminished numbers of developing and ovulated follicles (based on numbers of corpora lutea) vs. control littermates
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• diabetic female mice exhibit diminished numbers of developing and ovulated follicles (based on numbers of corpora lutea) vs. control littermates
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• homozygous mutant females produce fewer and smaller litters than do littermate controls
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cellular
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• mutant female mice have fewer primary oocytes and follicles than do control littermates
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